Intoduction: A highly efficient protocol for the one pot synthesis of 4(3H)-quinazolinones
from anthranilic acid, ortho esters and various amines using a magnetically separable solid acid catalyst,
nano sulfated TiO2 encapsulated Fe3O4 with microwave irradiation, is described. The plausible reaction
mechanism for the synthesis of 4(3H)-quinazolinone, catalyzed by sulfated TiO2 encapsulated magnetic
nanomaterial is also described.
Conclusion: The developed process has been successfully applied for the synthesis of diverse 4(3H)-
quinazolinones with variable functionality. This approach overcomes many of the drawbacks of the existing
methods and provides an environmentally benign process.