Our society is currently experiencing increased lifespan; one of the top causes for the high incidence of
neurodegenerative disorders. The lack of effective treatments delaying or blocking disease progression has encouraged
the active search for novel therapies. Many evidences support the protective role of phytochemicals in
the prevention of neurodegenerative diseases, particularly (poly)phenols. In this review, we described the use of
cellular-based models of neurodegenerative diseases and the benefits of their use as potent tools in the search for
bioactive molecules, particularly (poly)phenols. Studies to assess the biological activity of (poly)phenols involve
experimentation with in vitro and in vivo systems. In vitro systems are a useful tool as a first approach to test the
underlined molecular mechanisms of candidate molecules. They can provide valuable information about biological
activity, which can be then used to design animal and human intervention studies.
Keywords: 2D and 3D cells models, neurodegenerative diseases, oxidative stress, polyphenol, yeast, phytochemicals.
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