Title:Therapeutic Advancement in Alzheimer Disease: New Hopes on the Horizon?
VOLUME: 17 ISSUE: 8
Author(s):Ajeet Singh, Abshar Hasan, Sakshi Tiwari and Lalit M. Pandey*
Affiliation:Department of Biosciences and Bioengineering, Indian Institute of Technology, Guwahati, Assam 781039, Department of Biosciences and Bioengineering, Indian Institute of Technology, Guwahati, Assam 781039, Department of Biosciences and Bioengineering, Indian Institute of Technology, Guwahati, Assam 781039, Department of Biosciences and Bioengineering, Indian Institute of Technology, Guwahati, Assam 781039
Keywords:Alzheimer`s disease, Amyloid precursor protein intracellular domain, amyloidogenic precursor protein, glycogen
synthase kinase 3-beta, N-methyl-D-aspartate receptor, dementia.
Abstract:Background & Objective: Over the last two decades, Alzheimer disease (AD) associated
research has accomplished an overwhelming momentum, as it is one of the major current healthcare
issues in the developed world. AD is characterized by the presence of Aβ mediated extracellular amyloid
fibrils and tau-mediated intracellular neurofibrillar tangles and reports have highlighted their subsequent
effects on neuronal synaptic activity, antioxidant response and recently explored mitochondrial
dysfunction. Additionally, recent reports have demonstrated the mitochondrial dysfunction and
associated physiological as well as cellular alterations triggered by fibrillar structures inside the brain
tissue. Accumulated evidence indicated that mitochondrial dysfunction also plays a detrimental role in
AD pathogenesis and reduction in mitochondrial dysfunction may provide an additional beneficial effect
in AD patients. Currently available drugs are ineffective in disease progression and more symptomatic
while mechanism oriented drug explorations have been intensively investigated. Therefore,
search for effective therapeutic approaches in Alzheimer disease has directed the ongoing research
more towards specific biomarker selection, physicochemical properties of drugs and its subsequent interaction
with target molecules.
Conclusion: In present review, we have comprised an overview of the therapeutic advancement in
Alzheimer disease with a prevalent hypothesis and current ongoing putative therapeutic approaches to
provide recent insights in AD pathogenesis.
