Background and Aims: It is unclear whether white blood cell on admission has a prognosis
value on ischemic stroke and whether its function is affected by other inflammation factors.
We hypothesized that elevated white blood cell is associated with stroke severity and 3-month
mortality after acute ischemic stroke.
Methods: A total of 3891 acute ischemic stroke subjects from the China Antihypertensive Trial in
Acute Ischemic Stroke (CATIS) were included in this analysis. Participants were divided into four
groups according to quartiles of white blood cell on admission (cutoff points for the quintiles:
5.60×109/L,6.83×109/L,8.50×109/L). The primary outcome was a combination of death and
major disability (modified Rankin Scale score ≥3) at 3 months. Secondary outcomes were major
disability, death, and vascular events, respectively.
Results: After adjustment for major conventional risk factors, elevated white blood cell on admission
was associated with poor primary and secondary outcomes after acute ischemic stroke. Compared
with the lowest quartile, the ORs (95% CIs) for the highest quartile were 1.79 (1.37-2.91)
and 1.62 (1.21-3.55) for primary outcome in model 1 and model 2. In addition, there was a linear
association between white blood cell and primary outcome at 3-months (P for linear trend =
Conclusion: This analysis indicated that elevated white blood cell on admission is associated with
3-months poor prognosis in ischemic stroke patients independently of other inflammation factors.
The results emphasize the need for further research on the application of anti-inflammatory