Nucleophilic Vinyl/Allyl, CF3 and CF2α Perfluoroalkyl Groups Substitution and/or E1CB Elimination Reactions of Fluorine Atom(s) in Organofluorinated Compounds

Author(s): Nejib Hussein Mekni*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 16 , Issue 5 , 2019

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Graphical Abstract:


Direct substitution and elimination reactions of the fluorine atoms of difluoromethylene CF2α groups of nonspaced perfluoroalkyl chains, CF3 groups are very difficult to achieve. But, they become feasible with fluoro-alkenes, alkynes, imines or carbonyl derivatives, for which vinylic substitution and related carbanion-mediated pathways are available. In this review, we classify the major and unique fluorine substitution/elimination and rearrangement reactions and discuss their contribution to the synthesis of heterocyclic compounds.

Keywords: Fluorine elimination/substitution, perfluoroalkyl chain, trifluoromethyl, vinylic fluorine, allylic fluorine, organofluorinated compounds.

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Year: 2019
Page: [453 - 462]
Pages: 10
DOI: 10.2174/1570193X15666180626130042
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