[1]
ORGANIZATION, F.A.A. Faostat. 2012 ed.; Food and agriculture organization of the United Nations: US 2012.
[2]
Coursey, D.G. Yams: An account of the nature, origins, cultivation and utilization of the useful members of the dioscoreaceae; Longman, 1995.
[3]
Commission, C.P. Pharmacopoeia of People’s Republic of China. China, 2010, 1(27), 271.
[4]
(a)Fu, S.L.; Hsu, Y.H.; Lee, P.Y.; Hou, W.C.; Hung, L.C.; Lin, C.H.; Chen, C.M.; Huang, Y.J. Dioscorin isolated from Dioscorea alata activates TLR4-signaling pathways and induces cytokine expression in macrophages. Biochem. Biophys. Res. Commun., 2006, 339(1), 137-144.
(b)Liu, Y.W.; Shang, H.F.; Wang, C.K.; Hsu, F.L.; Hou, W.C. Immunomodulatory activity of dioscorin, the storage protein of yam (Dioscorea alata cv. Tainong No. 1) tuber. Food Chem. Toxicol., 2007, 45(11), 2312-2318.
[5]
Lin, P.L.; Lin, K.W.; Weng, C.F.; Lin, K.C. Yam storage protein dioscorins from Dioscorea alata and Dioscorea japonica exhibit distinct immunomodulatory activities in mice. J. Agric. Food Chem., 2009, 57(11), 4606-4613.
[6]
Liu, Y.W.; Liu, J.C.; Huang, C.Y.; Wang, C.K.; Shang, H.F.; Hou, W.C. Effects of oral administration of yam tuber storage protein, dioscorin, to BALB/c mice for 21-days on immune responses. J. Agric. Food Chem., 2009, 57(19), 9274-9279.
[7]
Hsu, Y.J.; Weng, C.F.; Lin, K.W.; Lin, K.C. Suppression of allergic reactions in ovalbumin-sensitized mice by yam storage proteins dioscorins. J. Agric. Food Chem., 2013, 61(47), 11460-11467.
[8]
Jheng, Y.J.; Tsai, W.Y.; Chen, K.H.; Lin, K.W.; Chyan, C.L.; Yang, C.C.; Lin, K.C. Recombinant dioscorins of the yam storage protein expressed in Escherichia coli exhibit antioxidant and immunomodulatory activities. Protein Expr. Purif., 2012, 85(1), 77-85.
[9]
Yang, C.C.; Lin, K.C. Class A dioscorins of various yam species suppress ovalbumin-induced allergic reactions. Immunopharmacol. Immunotoxicol., 2014, 36(3), 242-249.
[10]
Lee, S.J.; Lim, K.T. Inhibitory effect of 30-kDa phytoglycoprotein on expression of TNF-alpha and COX-2 via activation of PKCalpha and ERK 1/2 in LPS-stimulated RAW 264.7 cells. Mol. Cell. Biochem., 2008, 317(1-2), 151-159.
[11]
Lee, S.J.; Lim, K.T. Phytoglycoprotein inhibits interleukin-1beta and interleukin-6 via p38 mitogen-activated protein kinase in lipopolysaccharide-stimulated RAW 264.7 cells. Naunyn Schmiedebergs Arch. Pharmacol., 2008, 377(1), 45-54.
[12]
Oh, P.S.; Lim, K.T. Plant glycoprotein modulates the expression of interleukin-1beta via inhibition of MAP kinase in HMC-1 cells. Biosci. Biotechnol. Biochem., 2008, 72(8), 2133-2140.
[13]
Huong, P.T.; Lee, M.Y.; Lee, K.Y.; Chang, I.Y.; Lee, S.K.; Yoon, S.P.; Lee, D.C.; Jeon, Y.J. Synergistic induction of iNOS by IFN-γ and glycoprotein isolated from Dioscorea batatas. Korean J. Physiol. Pharmacol., 2012, 16(6), 431-436.
[14]
Huong, P.T.; Lee, C.H.; Li, M.H.; Lee, M.Y.; Kim, J.K.; Lee, S.M.; Seon, J.H.; Lee, D.C.; Jeon, Y.J. Characterization and immunopotentiating effects of the glycoprotein isolated from Dioscorea batatas. Korean J. Physiol. Pharmacol., 2011, 15(2), 101-106.
[15]
Nagai, T.; Nagashima, T. Functional properties of dioscorin, a soluble viscous protein from Japanese yam (Dioscorea opposita thunb.) tuber mucilage Tororo. Z. Naturforsch. C, 2006, 61(11-12), 792-798.
[16]
Nagai, T.; Suzuki, N.; Kai, N.; Tanoue, Y. Functional properties of autolysate and enzymatic hydrolysates from yam tsukuneimo (Dioscorea opposita Thunb.) tuber mucilage tororo: Antioxidative activity and antihypertensive activity. J. Food Sci. Technol., 2014, 51(12), 3838-3845.
[17]
Han, C.H.; Lin, Y.F.; Lin, Y.S.; Lee, T.L.; Huang, W.J.; Lin, S.Y.; Hou, W.C. Effects of yam tuber protein, dioscorin, on attenuating oxidative status and learning dysfunction in d-galactose-induced BALB/c mice. Food Chem. Toxicol., 2014, 65, 356-363.
[18]
Hsu, J.Y.; Chu, J.J.; Chou, M.C.; Chen, Y.W. Dioscorin pre-treatment protects A549 human airway epithelial cells from hydrogen peroxide-induced oxidative stress. Inflammation, 2013, 36(5), 1013-1019.
[19]
Hou, W.C.; Lee, M.H.; Chen, H.J.; Liang, W.L.; Han, C.H.; Liu, Y.W.; Lin, Y.H. Antioxidant activities of dioscorin, the storage protein of yam (Dioscorea batatas Decne) tuber. J. Agric. Food Chem., 2001, 49(10), 4956-4960.
[20]
Liu, Y.M.; Lin, K.W. Antioxidative ability, dioscorin stability, and the quality of yam chips from various yam species as affected by processing method. J. Food Sci., 2009, 74(2), C118-C125.
[21]
Han, C.H.; Liu, J.C.; Fang, S.U.; Hou, W.C. Antioxidant activities of the synthesized thiol-contained peptides derived from computer-aided pepsin hydrolysis of yam tuber storage protein, dioscorin. Food Chem., 2013, 138(2-3), 923-930.
[22]
Liao, Y.H.; Wang, C.H.; Tseng, C.Y.; Chen, H.L.; Lin, L.L.; Chen, W. Compositional and conformational analysis of yam proteins by near infrared fourier transform Raman spectroscopy. J. Agric. Food Chem., 2004, 52(26), 8190-8196.
[23]
Tsai, W.Y.; Jheng, Y.J.; Chen, K.H.; Lin, K.W.; Ho, Y.P.; Yang, C.C.; Lin, K.C. Molecular cloning, structural analysis and mass spectrometric identification of native dioscorins of various yam species. J. Sci. Food Agric., 2013, 93(4), 761-770.
[24]
Gaidamashvili, M.; Ohizumi, Y.; Iijima, S.; Takayama, T.; Ogawa, T.; Muramoto, K. Characterization of the yam tuber storage proteins from Dioscorea batatas exhibiting unique lectin activities. J. Biol. Chem., 2004, 279(25), 26028-26035.
[25]
Oh, P.S.; Lim, K.T. Blocking of intracellular ROS production by phytoglycoprotein (30 kDa) causes anti-proliferation in bisphenol A-stimulated chang liver cells. J. Appl. Toxicol., 2008, 28(6), 749-758.
[26]
Lok Wong, K.; Ming , Lai. Y.; Li, K.W.; Fai Lee, K.; Ng, T.B.; Pan Cheung, H.; Bo Zhang, Y.; Lao, L.; Ngok-Shun Wong, R.; Chui Shaw, P.; Ho Wong, J.; Zhang, Z.J.; Lam, J.K.; Wencai, Y.E.; Wing Sze, S.C. A novel, stable, estradiol-stimulating, osteogenic yam protein with potential for the treatment of menopausal syndrome. Sci. Rep., 2015, 5, 10179.
[27]
Lu, Y.L.; Chia, C.Y.; Liu, Y.W.; Hou, W.C. Biological activities and applications of dioscorins, the major tuber storage proteins of yam. J. Tradit. Complement. Med., 2012, 2(1), 41-46.
[28]
Hsu, F.L.; Lin, Y.H.; Lee, M.H.; Lin, C.L.; Hou, W.C. Both dioscorin, the tuber storage protein of yam (Dioscorea alata cv. Tainong No. 1), and its peptic hydrolysates exhibited angiotensin converting enzyme inhibitory activities. J. Agric. Food Chem., 2002, 50(21), 6109-6113.
[29]
Hou, W.C.; Liu, J.S.; Chen, H.J.; Chen, T.E.; Chang, C.F.; Lin, Y.H. Dioscorin, the major tuber storage protein of yam (Dioscorea batatas decne) with carbonic anhydrase and trypsin inhibitor activities. J. Agric. Food Chem., 1999, 47(5), 2168-2172.
[30]
Xue, Y.L.; Miyakawa, T.; Sawano, Y.; Tanokura, M. Cloning of genes and enzymatic characterizations of novel dioscorin isoforms from Dioscorea japonica. Plant Sci., 2012, 183, 14-19.
[31]
Araki, T.; Funatsu, J.; Kuramoto, M.; Konno, H.; Torikata, T. The complete amino acid sequence of yam (Dioscorea japonica) chitinase. A newly identified acidic class I chitinase. J. Biol. Chem., 1992, 267(28), 19944-19947.
[32]
Araki, T.; Kuramoto, M.; Torikata, T. Positions of disulfide bonds in yam (Dioscorea japonica) acidic class IL (class IV) chitinase. Arch. Biochem. Biophys., 1996, 335(1), 118-122.
[33]
Fu, L.S.; Ko, Y.H.; Lin, K.W.; Hsu, J.Y.; Chu, J.J.; Chi, C.S. Dioscorin protects tight junction protein expression in A549 human airway epithelium cells from dust mite damage. J. Microbiol. Immunol. Infect., 2009, 42(6), 457-463.
[34]
Ohizumi, Y.; Gaidamashvili, M.; Ohwada, S.; Matsuda, K.; Kominami, J.; Nakamura-Tsuruta, S.; Hirabayashi, J.; Naganuma, T.; Ogawa, T.; Muramoto, K. Mannose-binding lectin from yam (Dioscorea batatas) tubers with insecticidal properties against Helicoverpa armigera (Lepidoptera: Noctuidae). J. Agric. Food Chem., 2009, 57(7), 2896-2902.
[35]
Chan, Y.S.; Ng, T.B. A lectin with highly potent inhibitory activity toward breast cancer cells from edible tubers of Dioscorea opposita cv. nagaimo. PLoS One, 2013, 8(1), e54212.
[36]
Oh, P.S.; Lim, K.T. Protective activity of 30kDa phytoglycoprotein from glucose/glucose oxidase-induced cell death in primary cultured mouse thymocytes. Environ. Toxicol. Pharmacol., 2008, 25(1), 114-120.
[37]
Xue, Y.L.; Miyakawa, T.; Sawano, Y.; Tanokura, M. Crystallization and preliminary X-ray crystallographic analysis of dioscorin from Dioscorea japonica. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 2012, 68(Pt 2), 193-195.
[38]
Yen, M.L.; Su, J.L.; Chien, C.L.; Tseng, K.W.; Yang, C.Y.; Chen, W.F.; Chang, C.C.; Kuo, M.L. Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts. Mol. Pharmacol., 2005, 68(4), 1061-1073.
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