Abstract
Lectins are proteins or glycoproteins of non-immune origin which have at least one noncatalytic domain that bind reversibly to specific mono or oligosaccharides. Traditional Chinese Medicine (TCM) involves a broad range of medicinal practices sharing common concepts which have been developed in China and are based on a tradition of more than thousands of years. Plant materials which are commonly used in TCM as a complementary or alternative for Western medical treatments contain a considerable number of important lectins. These lectins have been reported to have various applications and uses such as cancer treatment, glycoconjugate research, biomarker development, and others. Here, we summarize the available literature related to lectins from TCM and recent trends in their potential biomedical applications.
Keywords: Lectins, traditional chinese medicine, cancer treatments, glycoconjugates research, biomarker development.
[1]
Peumans, W.J.; Van Damme, E.J.M. Lectins as plant defense proteins. Plant Physiol., 1995, 109, 347-352.
[2]
Chen, Z.; Kai, G.; Liu, X.; Lin, J.; Sun, X.; Tang, K. cDNA cloning and characterization of a mannose-binding lectin from Zingiber officinale Roscoe (ginger) rhizomes. J. Biosci., 2005, 30, 213-220.
[3]
Jung, E.C.; Kim, K.D.; Bae, C.H.; Kim, J.C.; Kim, D.K.; Kim, H.H. A mushroom lectin from Ascomycete cordyceps militaris. Biochim. Biophys. Acta, 2007, 1770, 833-838.
[4]
Siew, Y.Y.; Zareisedehizadeh, S.; Seetoh, W.G.; Neo, S.Y.; Tan, C.H.; Koh, H.L. Ethnobotanical survey of usage of fresh medicinal plants in Singapore. J. Ethnopharmacol., 2014, 155, 1450-1466.
[5]
Zuo, G.Y.; Zhang, X.J.; Yang, C.X.; Han, J.; Wang, G.C.; Bian, Z.Q. Evaluation of traditional Chinese medicinal plants for anti-MRSA activity with reference to the treatment record of infectious diseases. Molecules, 2012, 17, 2955-2967.
[6]
Zhou, J.; Zhou, T.; Jiang, M.; Wang, X.; Liu, Q.; Zhan, Z.; Zhang, X. Research progress on synergistic anti-tumor mechanisms of compounds in traditional Chinese medicine. J. Tradit. Chin. Med., 2014, 34, 100-105.
[7]
Ling, C.Q.; Yue, X.Q.; Ling, C. Three advantages of using traditional Chinese medicine to prevent and treat tumor. J. Integr. Med., 2014, 12, 331-335.
[8]
Zhang, Y.; Lin, H.S. Reasonable compatibility of effective components in Traditional Chinese Medicine is the route one must take medicine for the prevention and treatment of cancer. Zhong Guo Zhong Yi Yao Xin Xi Za Zhi, 2009, 16, 10-11.
[9]
Wang, X.M.; Zhang, J.; Wu, L.H.; Zhao, Y.L.; Li, T.; Li, J.Q.; Wang, Y.Z.; Liu, H.G. A mini-review of chemical composition and nutritional value of edible wild-grown mushroom from China. Food Chem., 2014, 151, 279-285.
[10]
Thakur, A.; Rana, M.; Lakhanpal, T.N.; Ahmad, A.; Khan, M.I. Purification and characterization of lectin from fruiting body of Ganoderma lucidum: Lectin from Ganoderma lucidum. Biochim. Biophys. Acta, 2007, 1770, 1404-1412.
[11]
Kawagishi, H.; Mitsunaga, S.; Yamawaki, M.; Ido, M.; Shimada, A.; Kinoshita, T.; Murata, T.; Usui, T.; Kimura, A.; Chiba, S. A lectin from mycelia of the fungus Ganoderma lucidum. Phytochemistry, 1997, 44, 7-10.
[13]
Thakur, A.; Pal, L.; Ahmad, A.; Khan, M.I. Complex carbohydrate specificity of lectin from fruiting body of Ganoderma lucidum. A surface plasmon resonance study. IUBMB Life, 2007, 59(12), 758-764.
[14]
U., Girjal V.; Neelagund, S.; Krishnappa, M. Ganoderma lucidum: A source for novel bioactive lectin. Protein Pept. Lett., 2011, 18, 1150-1157.
[15]
Ghosh, S.; Bishayee, K.; Khuda-Bukhsh, A.R. Oleanolic acid isolated from ethanolic extract of Phytolacca decandra induces apoptosis in A375 skin melanoma cells: Drug-DNA interaction and signaling cascade. J. Integr. Med., 2014, 12, 102-114.
[16]
Reisfeld, R.A.; Börjeson, J.; Chessin, L.N.; Small, P.A. Jr. Isolation and characterization of a mitogen from pokeweek (Phytolacca americana). Proc. Natl. Acad. Sci. USA, 1967, 58, 2020-2027.
[17]
Basham, T.Y.; Toyoshima, S.; Finkelman, F.; Waxdal, M.J. A series of murine interleukin molecules which stimulate both murine and human lymphocytes. I. Production by Phytolacca americana (pokeweed) lectin 2 (Pa-2)-stimulated thymus and thymus-derived cells. Cell. Immunol., 1981, 63, 118-133.
[18]
Yamaguchi, K.; Mori, A.; Funatsu, G. Amino acid sequence and some properties of lectin-D from the roots of pokeweed (Phytolacca americana). Biosci. Biotechnol. Biochem., 1996, 60, 1380-1382.
[19]
Fujii, T.; Hayashida, M.; Hamasu, M.; Ishiguro, M.; Hata, Y. Structures of two lectins from the roots of pokeweed (Phytolacca americana). Acta Crystallogr. D Biol. Crystallogr., 2004, 60, 665-673.
[20]
Kino, M.; Yamaguchi, K.; Umekawa, H.; Funatsu, G. Purification and characterization of three mitogenic lectins from the roots of pokeweed (Phytolacca americana). Biosci. Biotechnol. Biochem., 1995, 59, 683-688.
[21]
Yamaguchi, K.; Mori, A.; Funatsu, G. The complete amino acid sequence of lectin-C from the roots of pokeweed (Phytolacca americana). Biosci. Biotechnol. Biochem., 1995, 59, 1384-1385.
[22]
Yamaguchi, K.; Yurino, N.; Kino, M.; Ishiguro, M.; Funatsu, G. The amino acid sequence of mitogenic lectin-B from the roots of pokeweed (Phytolacca americana). Biosci. Biotechnol. Biochem., 1997, 61, 690-698.
[23]
Hayashida, M.; Fujii, T.; Hamasu, M.; Ishiguro, M.; Hata, Y. Crystallization and preliminary X-ray analysis of lectin C from the roots of pokeweed (Phytolacca americana). Acta Crystallogr. D Biol. Crystallogr., 2003, 59, 1249-1252.
[24]
Fang, E.F.; Zhang, C.Z.; Ng, T.B.; Wong, J.H.; Pan, W.L.; Ye, X.J.; Chan, Y.S.; Fong, W.P. Momordica charantia lectin, a type II ribosome inactivating protein, exhibits antitumor activity toward human nasopharyngeal carcinoma cells in vitro and in vivo. Cancer Prev. Res. (Phila.), 2012, 5, 109-121.
[25]
Ng, T.B.; Wong, C.M.; Li, W.W.; Yeung, H.W. Isolation and characterization of a galactose binding lectin with insulinomimetic activities. From the seeds of the bitter gourd Momordica charantia (Family Cucurbitaceae). Int. J. Pept. Protein Res., 1986, 28, 163-172.
[26]
Licastro, F.; Franceschi, C.; Barbieri, L.; Stirpe, F. Toxicity of Momordica charantia lectin and inhibitor for human normal and leukaemic lymphocytes. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol., 1980, 33, 257-265.
[27]
Zhang, C.Z.; Fang, E.F.; Zhang, H.T.; Liu, L.L.; Yun, J.P. Momordica Charantia lectin exhibits antitumor activity towards hepatocellular carcinoma. Invest. New Drugs, 2015, 33(1), 1-11.
[28]
Lin, J.Y.; Hou, M.J.; Chen, Y.C. Isolation of toxic and non-toxic lectins from the bitter pear melon Momordica charantia Linn. Toxicon, 1978, 16, 653-660.
[29]
Barbieri, L.; Lorenzoni, E.; Stirpe, F. Inhibition of protein synthesis in vitro by a lectin from Momordica charantia and by other haemagglutinins. Biochem. J., 1979, 182, 633-635.
[30]
Wong, J.H.; Wang, H.; Ng, T.B. A haemagglutinin from the medicinal fungus Cordyceps militaris. Biosci. Rep., 2009, 29, 321-327.
[31]
Deng, J.L.; Zeng, Z.K.; Yan, B.; Huang, X.Q. Purification and characterization of Sophora flavescens lectin. Acta Bot. Sin., 2000, 42, 828-833.
[32]
Shi, Z.; Chen, J.; Li, C.Y.; An, N.; Wang, Z.J.; Yang, S.L.; Huang, K.F.; Bao, J.K. Antitumor effects of concanavalin A and Sophora flavescens lectin in vitro and in vivo. Acta Pharmacol. Sin., 2014, 35, 248-256.
[33]
Liu, Z.; Liu, B.; Zhang, Z.T.; Zhou, T.T.; Bian, H.J.; Min, M.W.; Liu, Y.H.; Chen, J.; Bao, J.K. A mannose-binding lectin from Sophora flavescens induces apoptosis in HeLa cells. Phytomedicine, 2008, 15, 867-875.
[34]
Li, C.; Chen, J.; Lu, B.; Shi, Z.; Wang, H.; Zhang, B.; Zhao, K.; Qi, W.; Bao, J.; Wang, Y. Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PLoS One, 2014, 9, e101526.
[35]
Lu, Y.L.; Chia, C.Y.; Liu, Y.W.; Hou, W.C. Biological activities and applications of dioscorins, the major tuber storage proteins of yam. J. Tradit. Complement. Med., 2012, 2, 41-46.
[36]
Gaidamashvili, M.; Ohizumi, Y.; Iijima, S.; Takayama, T.; Ogawa, T.; Muramoto, K. Characterization of the yam tuber storage proteins from Dioscorea batatas exhibiting unique lectin activities. J. Biol. Chem., 2004, 279, 26028-26035.
[37]
Ohizumi, Y.; Gaidamashvili, M.; Ohwada, S.; Matsuda, K.; Kominami, J.; Nakamura-Tsuruta, S.; Hirabayashi, J.; Naganuma, T.; Ogawa, T.; Muramoto, K. Mannose-binding lectin from yam (Dioscorea batatas) tubers with insecticidal properties against Helicoverpa armigera (Lepidoptera: Noctuidae). J. Agric. Food Chem., 2009, 57, 2896-2902.
[38]
Zhang, W.; Tian, G.; Geng, X.; Zhao, Y.; Ng, T.B.; Zhao, L.; Wang, H. Isolation and characterization of a novel lectin from the edible mushroom Stropharia rugosoannulata. Molecules, 2014, 19, 19880-19891.
[39]
Peumans, W.J.; Zhang, W.; Barre, A.; Houlès Astoul, C.; Balint-Kurti, P.J.; Rovira, P.; Rougé, P.; May, G.D.; van Leuven, F.; Truffa-Bachi, P.; Van Damme, E.J. Fruit-specific lectins from banana and plantain. Planta, 2000, 211, 546-554.
[40]
Singh, S.S.; Devi, S.K.; Ng, T.B. Banana lectin: A brief review. Molecules, 2014, 19, 18817-18827.
[41]
Balzarini, J.; Schols, D.; Neyts, J.; van Damme, E.; Peumans, W.; de Clercq, E. α-(1–3)- and α-(1–6)-D-Mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro. Antimicrob. Agents Chemother., 1991, 35, 410-416.
[42]
Wearne, K.; Winter, H.C.; Goldstein, I.J. Isolation of banana lectin-A practical scale procedure from ripe banana fruit. Prep. Biochem. Biotechnol., 2013, 43, 285-292.
[43]
Swanson, M.D.; Winter, H.C.; Goldstein, I.J.; Markovitz, D.M. A lectin isolated from bananas is a potent inhibitor of HIV replication. J. Biol. Chem., 2010, 285, 8646-8655.
[44]
Li, X.; Lu, P.; Zhang, W.; Li, B.; Yang, R.; Luo, K. Study on anti-Ehrlich ascites tumour effect of Pinellia ternata polysaccharide in vivo. Afr. J. Tradit. Complement. Altern. Med., 2013, 10, 380-385.
[45]
Shih, Y.L.; Wang, W.P.; Zhang, H.; Wang, K.Y.; Guo, M. Cation channels formed in lipid bilayer by Pinellia ternata lectin. Sheng Li Xue Bao, 1992, 44, 142-148.
[46]
Shi, Y.L.; Xu, Y.F.; Zhang, H. Effect of Pinellia ternata lectin on membrane currents of mouse motor nerve terminals. Sci. China B., 1994, 37, 448-453.
[47]
He, X.M.; Ji, N.; Xiang, X.C.; Luo, P.; Bao, J.K. Purification, characterization, and molecular cloning of a novel antifungal lectin from the roots of Ophioglossum pedunculosum. Appl. Biochem. Biotechnol., 2011, 165, 1458-1472.
[48]
Wu, A.M.; Wu, J.H.; Tsai, M.S.; Herp, A. Carbohydrate specificity of an agglutinin isolated from the root of Trichosanthes kirilowii. Life Sci., 2000, 66, 2571-2581.
[49]
Gong, F.; Ma, Y.; Ma, A.; Yu, Q.; Zhang, J.; Nie, H.; Chen, X.; Shen, B.; Li, N.; Zhang, D. A lectin from Chinese mistletoe increases gammadelta T cell-mediated cytotoxicity through induction of caspase-dependent apoptosis. Acta Biochim. Biophys. Sin. (Shanghai), 2007, 39, 445-452.
[50]
Ma, Y.H.; Cheng, W.Z.; Gong, F.; Ma, A.L.; Yu, Q.W.; Zhang, J.Y.; Hu, C.Y.; Chen, X.H.; Zhang, D.Q. Active Chinese mistletoe lectin-55 enhances colon cancer surveillance through regulating innate and adaptive immune responses. World J. Gastroenterol., 2008, 14, 5274-5281.
[51]
Wang, Y.; Shi, L.L.; Wang, L.Y.; Xu, J.W.; Feng, Y. Protective effects of mdg-1, a polysaccharide from ophiopogon japonicus on diabetic nephropathy in diabetic KKA(y) mice. Int. J. Mol. Sci., 2015, 16, 22473-22484.
[52]
Tian, Q.; Wang, W.; Miao, C.; Peng, H.; Liu, B.; Leng, F.; Dai, L.; Chen, F.; Bao, J. Purification, characterization and molecular cloning of a novel mannose-binding lectin from rhizomes of Ophiopogon japonicas with antiviral and antifungal activities. Plant Sci., 2008, 175(6), 877-884.
[53]
Liu, B.; Peng, H.; Yao, Q.; Li, J.; Van Damme, E.; Balzarini, J.; Bao, J.K. Bioinformatics analyses of the mannose-binding lectins from Polygonatum cyrtonema, Ophiopogon japonicus and Liparis noversa with antiproliferative and apoptosis-inducing activities. Phytomedicine, 2009, 6-7, 601-608.
[54]
Bastiaan-Net, S.; Chanput, W.; Hertz, A.; Zwittink, R.D.; Mes, J.J.; Wichers, H.J. Biochemical and functional characterization of recombinant fungal immunomodulatory proteins (rFIPs). Int. Immunopharmacol., 2013, 15, 167-175.
[55]
Liao, C.H.; Hsiao, Y.M.; Hsu, C.P.; Lin, M.Y.; Wang, J.C.; Huang, Y.L.; Ko, J.L. Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line. Mol. Carcinog., 2006, 45, 220-229.
[56]
Liao, C.H.; Hsiao, Y.M.; Sheu, G.T.; Chang, J.T.; Wang, P.H.; Wu, M.F.; Shieh, G.J.; Hsu, C.P.; Ko, J.L. Nuclear translocation of telomerase reverse transcriptase and calcium signaling in repression of telomerase activity in human lung cancer cells by fungal immunomodulatory protein from Ganoderma tsugae. Biochem. Pharmacol., 2007, 74, 1541-1554.
[57]
De Mejía, E.G.; Prisecaru, V. Lectins as bioactive plant proteins: A potential in cancer treatment. Crit. Rev. Food Sci. Nutr., 2005, 45, 425-445.
[58]
Ge, Z.H.; Blom, J.; Larsson, L.I. Ulex europaeus agglutinin-I binds to developing gastrin cells. Histochem. Cell Biol., 1998, 109, 183-188.
[59]
Xiao, X.; He, H.; Ding, X.; Yang, Q.; Liu, X.; Liu, S.; Rang, J.; Wang, T.; Zuo, M.; Xia, L. Purification and cloning of lectin that induce cell apoptosis from Allium chinense. Phytomedicine, 2015, 22, 238-244.
[60]
Akev, N.; Turkay, G.; Can, A.; Gurel, A.; Yildiz, F.; Yardibi, H.; Ekiz, E.E.; Uzun, H. Tumour preventive effect of Aloe vera leaf pulp lectin (Aloctin I) on Ehrlich ascites tumours in mice. Phytother. Res., 2007, 21(11), 1070-1075.
[61]
Akev, N.; Can, A. Separation and some properties of Aloe vera L. leaf pulp lectins. Phytother. Res., 1999, 13(6), 489-493.
[62]
Ng, T.B.; Lam, Y.W. Isolation of a novel agglutinin with complex carbohydrate binding specificity from fresh fruiting bodies of the edible mushroom Lyophyllum shimeiji. Biochem. Biophys. Res. Commun., 2002, 290, 563-568.
[63]
Stanko, V.; Giuliani, C.; Retzer, K.; Djamei, A.; Wahl, V.; Wurzinger, B.; Wilson, C.; Heberle-Bors, T.M.; Kragler, F. Timing is everything: Highly specific and transient expression of a MAP kinase determines auxin-induced leaf venation patterns in Arabidopsis. Mol. Plant, 2014, 7, 1637-1652.
[65]
Wong, K.L.; Wong, R.N.; Zhang, L.; Liu, W.K.; Ng, T.B.; Shaw, P.C.; Kwok, P.C.; Lai, Y.M.; Zhang, Z.J.; Zhang, Y.; Tong, Y.; Cheung, H.P.; Lu, J.; Sze, S.C. Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential. Chin. Med., 2014, 9, 19.
[66]
Yau, T.; Dan, X.; Ng, C.C.; Ng, T.B. Lectins with potential for anti-cancer therapy. Molecules, 2015, 20(3), 3791-3810.
[67]
Swanson, M.D.; Winter, H.C.; Goldstein, I.J.; Markovitz, D.M. A lectin isolated from bananas is a potent inhibitor of HIV replication. J. Biol. Chem., 2010, 285, 8646-8655.
[68]
Koshte, V.L.; van Dijk, W.; van der Stelt, M.E.; Aalberse, R.C. Isolation and characterization of BanLec-I, a mannoside-binding lectin from Musa paradisiaca (banana). Biochem. J., 1990, 272, 721-726.
[69]
Ahmad, E.; Kamranur Rahman, S.; Masood Khan, J.; Varshney, A.; Hasan Khan, R. Phytolacca americana lectin (Pa-2; pokeweed mitogen): An intrinsically unordered protein and its conversion into partial order at low pH. Biosci. Rep., 2009, 30, 125-134.
[70]
Fukumori, F.; Takeuchi, N.; Hagiwara, T.; Ohbayashi, H.; Endo, T.; Kochibe, N.; Nagata, Y.; Kobata, A. Primary structure of a fucose-specific lectin obtained from a mushroom, Aleuria aurantia. J. Biochem., 1990, 107, 190-196.
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