Background: In recent times sustainable organic transformations are the challenge for the
chemist in areas like environment, health, social sector and to overcome these troubles, it is planned to
develop simple and facile methods to carry organic reaction under benign media. Literature survey revealed
nano magnetite supported heterogeneous catalysis is a growing field in catalytic science with
huge application in organic synthesis. So in this present article our focus is on the synthesis of nanomagnetite
supported cysteine organocatalyst and their application in organic synthesis.
Methods: Nanocat-ferrite-L-cysteine was prepared by simple stirring technique in aqueous media followed
by dehydration technique. The prepared catalyst is well characterized by some analytical system
like FT-IR, TEM and FEG-SEM-EDS spectroscopy. This functionalised nanocat-Fe-Cys was employed
in the synthesis of bis(indolyl) methanes under solvent-free conditions. The % conversion of
products was checked by thin layer chromatography and the synthesized compounds were further confirmed
by NMR techniques.
Results: To check the competency of synthesized nanocat-Fe-Cys for bis(indolyl) methanes reaction,
a benign one step transformation reported under microwave irradiation method superiorly over conventional
oil bath method. The products were obtained in very clean & noticeably higher yield (80-
94%). The catalyst ferrite cysteine was found to be recyclable for ten times without any remarkable
damage in catalytic activity.
Conclusion: In present research article, the synthesis of highly active, recyclable & versatile organo
nanocatlyst ferrite-cysteine reported using easily available precursor via the simple impregnation
method. The MNPs was found to be stable under investigated conditions & highly effective in the synthesis
of bis(indolyl) methanes derivatives. The simple eco-friendly method, mild reaction conditions,
economically affordable and good product yields concentrate this attractive sustainable protocol.