Background: Gamma-Decanolactone (GD) is a monoterpene compound that presents anticonvulsant
effect in acute and chronic models of epilepsy and it acts as a noncompetitive glutamate
Objective: This study evaluated the anticonvulsant profile and the possible mechanism of action of
GD in seizures induced by isoniazid (INH; 250 mg/kg), picrotoxin (PCT; 5 mg/kg) and 4-
aminopyridine (4-AP; 13 mg/kg) in male mice.
Method: Thirty minutes before the convulsants administration, animals received a single administration
of saline, GD (100 or 300 mg/kg) or the positive control diazepam (DZP; 2 mg/kg). The parameters
evaluated were the latency to the first seizure and the occurrence of clonic forelimb seizures. The
rotarod performance test was used to evaluate the neurotoxicity of GD (300 mg/kg). Also, the DZPinduced
sleep test was used.
Results: DZP increased the latency to the first seizure on all used models and decreased the percentage
of seizures in two of the three behavioral models. GD was able to prolong the latency to the first
seizure and decreased the percentage of seizures induced by INH and 4-AP, but not by PCT. It reduced
the latency to fall off the rotarod test only at the time of 30 min. In the DZP-induced sleep test,
GD shortened the onset and prolonged the time of sleep.
Conclusion: Our findings suggested that GD reduced the convulsive behavior in the seizure models
used here and it could modulate GABA pathways and affect potassium channels directly or indirectly,
involving more than one cellular target in the central nervous system.