Oxidation of 2-(substituted thio) quinazolines in THF and aqueous media using stoichiometric
amounts of oxone afforded their corresponding 2-(substituted sulfonyl)quinazolines with excellent
selectivity (75-94% yield). This versatile synthetic protocol proved efficient with various substituted
thio quinazoline compounds as substrates. All the twelve products were characterized by melting
range, infrared, 1H-NMR, 13C-NMR and mass spectrometry.
Keywords: Oxone, sulfones, thioquinazolines, chemo-selective, optimization, m-CPBA.
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