Title:Oxone Mediated Oxidation of 2-(aryl/alkyl thio) Quinazolines: A Green Approach
VOLUME: 5 ISSUE: 2
Author(s):Satya Karuna Pulakhandam, Annem Siva Reddy, Naresh Kumar Katari*, Ravi Prakash Reddy Manda and Sreekantha B. Jonnalagadda*
Affiliation:Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh 533 003, Department of Chemistry, GITAM School of Technology, GITAM University, HTP campus, Rudraram, Medak, Telangana 502 329, Department of Chemistry, GITAM School of Technology, GITAM University, HTP campus, Rudraram, Medak, Telangana 502 329, C-MET, IDA Phase II, Cherlapally HCL (PO), Hyderabad, Telangana 500 057, School of Chemistry & Physics, University of KwaZulu-Natal, P Bag X 54001, Durban 4000
Keywords:Oxone, sulfones, thioquinazolines, chemo-selective, optimization, m-CPBA.
Abstract:Oxidation of 2-(substituted thio) quinazolines in THF and aqueous media using stoichiometric
amounts of oxone afforded their corresponding 2-(substituted sulfonyl)quinazolines with excellent
selectivity (75-94% yield). This versatile synthetic protocol proved efficient with various substituted
thio quinazoline compounds as substrates. All the twelve products were characterized by melting
range, infrared, 1H-NMR, 13C-NMR and mass spectrometry.