Abstract
Background: Immunosenescence is a remodeling of the immune system, caused by aging, with changes in the function of neutrophils, lymphocytes, and Treg cells.
Objective: This study aimed to evaluate the expression of molecules CD11b, CD16 and CD64 (neutrophils), CD154 (T lymphocytes), CD40 (B lymphocytes), and to quantitatively analyze the Treg cell subpopulation.
Methods: 49 elderlies (≥60 years) and 49 adults (≤35 years) were studied. Flow cytometry was used to analyze the expression of surface molecules and the subpopulation of Treg cells, and the results between the groups were compared statistically by the t-test.
Results: There was a decreased significance in the expression of CD11b and CD40 in the elderly.
Conclusion: Decreased CD11b expression can result in susceptibility to infectious diseases, and impairment of phagocytic capacity. Decreased CD40 expression can result in a decline in B lymphocyte activation. The other molecule studied presented alterations not significant, but compatible with the immunological changes in aging.
Keywords: Immunosenescence, aging, neutrophils, lymphocytes, CD11b, CD40.
Current Aging Science
Title:Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes
Volume: 11 Issue: 2
Author(s): Alessandra B. Lopes*, Larissa B. Lopes, Roseli N. da Silveira Antunes, Josianne T. Fukasawa, Débora de A. Cavaretto and Zamir Calamita
Affiliation:
- Postgraduate Program in Health and Aging, Marilia School of Medicine - FAMEMA, Rua Monte Carmelo, 800, Fragata, CEP: 17519-030, Marilia - SP,Brazil
Keywords: Immunosenescence, aging, neutrophils, lymphocytes, CD11b, CD40.
Abstract: Background: Immunosenescence is a remodeling of the immune system, caused by aging, with changes in the function of neutrophils, lymphocytes, and Treg cells.
Objective: This study aimed to evaluate the expression of molecules CD11b, CD16 and CD64 (neutrophils), CD154 (T lymphocytes), CD40 (B lymphocytes), and to quantitatively analyze the Treg cell subpopulation.
Methods: 49 elderlies (≥60 years) and 49 adults (≤35 years) were studied. Flow cytometry was used to analyze the expression of surface molecules and the subpopulation of Treg cells, and the results between the groups were compared statistically by the t-test.
Results: There was a decreased significance in the expression of CD11b and CD40 in the elderly.
Conclusion: Decreased CD11b expression can result in susceptibility to infectious diseases, and impairment of phagocytic capacity. Decreased CD40 expression can result in a decline in B lymphocyte activation. The other molecule studied presented alterations not significant, but compatible with the immunological changes in aging.
Export Options
About this article
Cite this article as:
Lopes B. Alessandra *, Lopes B. Larissa , da Silveira Antunes N. Roseli , Fukasawa T. Josianne , de A. Cavaretto Débora and Calamita Zamir , Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes, Current Aging Science 2018; 11 (2) . https://dx.doi.org/10.2174/1874609811666180605092234
DOI https://dx.doi.org/10.2174/1874609811666180605092234 |
Print ISSN 1874-6098 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-6128 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Ryanodine Receptor: A Pivotal Ca2+ Regulatory Protein and Potential Therapeutic Drug Target
Current Drug Targets Law-Medicine Interfacing: Patenting of Human Genes and Mutations
Recent Patents on DNA & Gene Sequences Prevention of Cardiovascular Complications in the Marfan Syndrome
Vascular Disease Prevention (Discontinued) Vascular Disease and Insulin-Like Growth Factor-1
Vascular Disease Prevention (Discontinued) Definition of Postprandial Lipaemia
Current Vascular Pharmacology "Heart Failure: Meeting the Challenges of Surveillance and Knowledge Translation in Resource-poor Settings"
Current Cardiology Reviews The Rabbit as an Experimental and Production Animal: From Genomics to Proteomics
Current Protein & Peptide Science Heart Score Estimation by Specialized Nurses in a Greek Urban Population
Current Vascular Pharmacology Aβ Monomers, Oligomers and Fibrils: Structural Features
Current Bioactive Compounds Role of Sympathetic Nerve Activity in Obesity, Hypertension and Metabolic Syndrome
Current Hypertension Reviews Genetics of Congenital Heart Disease
Current Cardiology Reviews The Use of Ghrelin and Ghrelin Receptor Agonists as a Treatment for Animal Models of Disease: Efficacy and Mechanism
Current Pharmaceutical Design Preface
Letters in Drug Design & Discovery Functional and Structural Benefits Induced by Omega-3 Polyunsaturated Fatty Acids During Aging
Current Neuropharmacology Gene-Activators Prevent and Regress Atherosclerosis and Reduce Mortality
Cardiovascular & Hematological Agents in Medicinal Chemistry Inhibition of Transcription Factors by Plant-Derived Compounds and their Implications in Inflammation and Cancer
Current Pharmaceutical Design Stem Cell Aging and Age-Related Cardiovascular Disease: Perspectives of Treatment by Ex-vivo Stem Cell Rejuvenation
Current Drug Targets Cellular Cardiomyoplasty – Challenges of a New Era
Current Tissue Engineering (Discontinued) Endoplasmic Reticulum Stress-induced Transcriptional Factor CHOP and Cardiovascular Diseases
Current Hypertension Reviews Fetal Arterial Changes in Response to Maternal Cigarette Smoking: Revisiting the Natural History of the Earliest Stage of Atherosclerosis
Current Cardiology Reviews