Medicinal Chemistry for Pharmacy Students

Medicinal Chemistry for Pharmacy Students

Volume: 1

Fundamentals of Medicinal Chemistry and Drug Metabolism

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of chemical ...
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Fundamentals of Drug Action

Pp. 160-187 (28)

M. O. Faruk Khan and Taufiq Rahman


This chapter is a brief review of the mechanistic aspects of drug action and discusses the concepts of receptors and drug receptor interactions critical for pharmacological responses of drugs. After study of this chapter, students will be able to: • Discuss about receptors from historical perspectives • Explain the mechanistic principles of drug action in light of receptors • Summarize different theories of drug action such as: - Occupancy Theory - Rate Theory - Induced-Fit Theory - Macromolecular Perturbation Theory - Occupation-Activation Theory of “Two-State” Model • Understand drug receptor interactions


Affinity, Agonist, Antagonist, Drug receptor interaction, Efficacy, Intrinsic activity, Partial agonist, Receptor, Theories of drug action.


Department of Pharmaceutical Sciences and Research, Marshall University School of Pharmacy, Huntington, WV, USA.