Abstract
Our previous work has indicated that miR-155 expression induces inflammatory responses in ischemic cerebral tissues. However, the delicate regulation of miR-155-modifed inflammatory responses has remained enigmatic. In the present study, we found that autophagy is induced by ischemia through miR-155 and involved in neural injury. Subsequently, miR-155- induced autophagy modifies inflammatory responses through regulating TLR4/NF-κB pathway in ischemic cerebral tissues. Thus, miR-155 elevated autophagy is detrimental for ischemic cerebral injury and miR-155-induced autophagy modulates inflammatory responses through activating TLR4/NF-κB pathway.
Keywords: miR-155, autophagy, inflammatory response, ischemic cerebral tissues, ischemic stroke, hypoxic damages.
Current Neurovascular Research
Title:MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy
Volume: 15 Issue: 2
Author(s): Yi Yang, Ning Zhang, Shan Wang and Ya Wen*
Affiliation:
- Department of Neurology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory for Neurology, Hebei, 050000,China
Keywords: miR-155, autophagy, inflammatory response, ischemic cerebral tissues, ischemic stroke, hypoxic damages.
Abstract: Our previous work has indicated that miR-155 expression induces inflammatory responses in ischemic cerebral tissues. However, the delicate regulation of miR-155-modifed inflammatory responses has remained enigmatic. In the present study, we found that autophagy is induced by ischemia through miR-155 and involved in neural injury. Subsequently, miR-155- induced autophagy modifies inflammatory responses through regulating TLR4/NF-κB pathway in ischemic cerebral tissues. Thus, miR-155 elevated autophagy is detrimental for ischemic cerebral injury and miR-155-induced autophagy modulates inflammatory responses through activating TLR4/NF-κB pathway.
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Cite this article as:
Yang Yi , Zhang Ning , Wang Shan and Wen Ya *, MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy, Current Neurovascular Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567202615666180601081409
DOI https://dx.doi.org/10.2174/1567202615666180601081409 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
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