Evaluation of Curcumin Gel as Adjunct to Scaling & Root Planing in Management of Periodontitis- Randomized Clinical & Biochemical Investigation

Author(s): Harleen Kaur*, Vishakha Grover*, Ranjan Malhotra, Mili Gupta

Journal Name: Infectious Disorders - Drug Targets
Formerly Current Drug Targets - Infectious Disorders

Volume 19 , Issue 2 , 2019

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Background: Successful management of periodontitis requires treatment strategy that integrates therapies addressing both pathogen and host aspects of disease etiology. To evaluate sub gingivally applied curcumin gel in treatment of chronic periodontitis based on clinical and biochemical parameters.

Materials & Methods: A randomized, double blind, parallel-group trial was carried out on 30 patients suffering from chronic generalized periodontitis with probing pocket depth≥5mm on at least 4 sites who were then randomly allocated to two groups. Control group was treated with Scaling and Root Planing (SRP) alone while experimental group was treated with SRP followed by subgingival application of curcumin gel. Saliva collection was done and the clinical parameters were recorded at baseline and follow up periods. Saliva analysis for IL-1β was done by ELISA. The statistical differences for the intra-group and intergroup measurements were analyzed by using Mann Whitney test. Spearman’s rank correlation coefficient was used to examine the relationship between Interleukin - 1β and clinical parameters.

Results: Study elucidated mild adjunctive benefit of curcumin gel in reduction of gingival inflammation for a limited period of time. Though improvement in other clinical parameters was also greater in subjects treated with curcumin gel, results were not statistically different from those treated with SRP alone. None of the subjects who received curcumin gel experienced any adverse effect.

Conclusion: Within limitations, it can be concluded that single application of curcumin (turmeric) gel has limited added benefit over scaling and root planing in treatment of chronic periodontitis.

Keywords: anti-inflammatory, antimicrobial, curcumin, host modulation, periodontitis, turmeric.

Eley, B.M.; Manson, J.D. Outline of Periodontics, 4th ed; , 2000.
Lindhe, J.; Lang, N.P.; Karring, T. Clinical Periodontology and Implant Dentistry, 5th ed; , 2008.
Newman, M.G.; Takei, H.H.; Klokkevold, P.R.; Carranza, F.A., Jr Carranza’s Clinical Periodontology, 11th ed; , 2012.
Suhag, A.; Dixit, J.; Dhan, P. Role of curcumin as a subgingival irrigant: a pilot study. Periodontal Practice Today, 2007, 4(2), 115-121.
Muglikar, S.; Patil, K.C.; Shivswami, S.; Hegde, R. Efficacy of curcumin in the treatment of chronic gingivitis: a pilot study. Oral Health Prev. Dent., 2013, 11(1), 81-86.
Nagpal, M.; Sood, S. Role of curcumin in systemic and oral health: An overview. J. Nat. Sci. Biol. Med., 2013, 4(1), 3-7.
Chaturvedi, T.P. Uses of turmeric in dentistry: an update. Indian J. Dent. Res., 2009, 20(1), 107-109.
Kohli, K.; Ali, J.; Ansari, M.J.; Raheman, Z. Curcumin: A natural anti-inflammatory agent. Indian J. Pharmacol., 2005, 37, 141-147.
Sidhu, G.S.; Singh, A.K.; Thaloor, D.; Banaudha, K.K.; Patnaik, G.K.; Srimal, R.C.; Maheshwari, R.K. Enhancement of wound healing by curcumin in animals. Wound Repair Regen., 1998, 6(2), 167-177.
Menon, V.P.; Sudheer, A.R. Antioxidant and anti-inflammatory properties of curcumin. Adv. Exp. Med. Biol., 2007, 595, 105-125.
Jurenka, J.S. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern. Med. Rev., 2009, 14(2), 141-153.
Thakur, N.; Ghezta, N. Curcumin. Guident, 2012, 5(5), 76-79.
Christodoulides, N.; Floriano, P.N.; Miller, C.S.; Ebersole, J.L.; Mohanty, S.; Dharshan, P.; Griffin, M.; Lennart, A.; Ballard, K.L.; King, C.P., Jr; Langub, M.C.; Kryscio, R.J.; Thomas, M.V.; McDevitt, J.T. Lab-on-a-chip methods for point-of-care measurements of salivary biomarkers of periodontitis. Ann. N. Y. Acad. Sci., 2007, 1098, 411-428.
Sexton, W.M.; Lin, Y.; Kryscio, R.J.; Dawson, D.R., III; Ebersole, J.L.; Miller, C.S. Salivary biomarkers of periodontal disease in response to treatment. J. Clin. Periodontol., 2011, 38(5), 434-441.
Thunell, D.H.; Tymkiw, K.D.; Johnson, G.K.; Joly, S.; Burnell, K.K.; Cavanaugh, J.E.; Brogden, K.A.; Guthmiller, J.M. A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy. J. Periodontal Res., 2010, 45(1), 148-152.
Grover, V.; Malhotra, R.; Sachdeva, S. Cytokines: the signaling molecules of periodontium, 1st ed; , 2011.
Kaushik, R.; Yeltiwar, R.K.; Pushpanshu, K. Salivary interleukin-1β levels in patients with chronic periodontitis before and after periodontal phase I therapy and healthy controls: a case-control study. J. Periodontol., 2011, 82(9), 1353-1359.
Miller, C.S.; King, C.P., Jr; Langub, M.C.; Kryscio, R.J.; Thomas, M.V. Salivary biomarkers of existing periodontal disease: a cross-sectional study. J. Am. Dent. Assoc., 2006, 137(3), 322-329.
Gomes, F.I.; Aragão, M.G.; Barbosa, F.C.; Bezerra, M.M.; de Paulo Teixeira Pinto, V.; Chaves, H.V. Inflammatory Cytokines Interleukin-1β and Tumour Necrosis Factor-α - Novel Biomarkers for the Detection of Periodontal Diseases: a Literature Review. J. Oral Maxillofac. Res., 2016, 7(2)e2
Sakalauskiene, J.; Giedrimiene, D.; Gleiznys, D.; Gleiznys, A.; Gleizniene, R.; Vitkauskiene, A. Peripheral Blood Leukocytes Interleukin-1 Beta (IL-1β) Cytokine Hyper-Reactivity in Chronic Periodontitis. Med. Sci. Monit., 2016, 22, 4323-4329.
Sexton, W.M.; Lin, Y.; Kryscio, R.J.; Dawson, D.R., III; Ebersole, J.L.; Miller, C.S. Salivary biomarkers of periodontal disease in response to treatment. J. Clin. Periodontol., 2011, 38(5), 434-441.
Ciancio, S.G. Current status of indices of gingivitis. J. Clin. Periodontol., 1986, 13(5), 375-378, 381-382.
Behal, R.; Mali, A.M.; Gilda, S.S.; Paradkar, A.R. Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: A clinical and microbiological study. J. Indian Soc. Periodontol., 2011, 15(1), 35-38.
Gottumukkala, S.N.V.S.; Koneru, S.; Mannem, S.; Mandalapu, N. Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trial. Contemp. Clin. Dent., 2013, 4(2), 186-191.
Gottumukkala, S.N.V.S.; Sudarshan, S.; Mantena, S.R. Comparative evaluation of the efficacy of two controlled release devices: Chlorhexidine chips and indigenous curcumin based collagen as local drug delivery systems. Contemp. Clin. Dent., 2014, 5(2), 175-181.
Engebretson, S.P.; Grbic, J.T.; Singer, R.; Lamster, I.B. GCF IL-1beta profiles in periodontal disease. J. Clin. Periodontol., 2002, 29(1), 48-53.
Offenbacher, S.; Barros, S.P.; Singer, R.E.; Moss, K.; Williams, R.C.; Beck, J.D. Periodontal disease at the biofilm-gingival interface. J. Periodontol., 2007, 78(10), 1911-1925.
Greenstein, G. Clinical versus statistical significance as they relate to the efficacy of periodontal therapy. J. Am. Dent. Assoc., 2003, 134(5), 583-591.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2019
Published on: 15 May, 2019
Page: [171 - 178]
Pages: 8
DOI: 10.2174/1871526518666180601073422
Price: $65

Article Metrics

PDF: 37
PRC: 1