Celiac Disease: Historical Standpoint, New Perspectives of Treatments and Contemporary Research Techniques

Author(s): Luciano A. Benedini*, Noelia L. Gonzalez Vidal, Maria Alejandra Gonzalez

Journal Name: Current Protein & Peptide Science

Volume 19 , Issue 11 , 2018

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Graphical Abstract:


Celiac disease (CD) is an inflammatory syndrome that affects mainly the intestine, but also other organs. This ailment is also affected by the physicochemical behavior of gluten as such. From the medical standpoint, this pathology results from a combination of genetic and environmental factors. At the same time, gliadin (the alcohol-soluble fraction of gluten) along with other related oligomers, such as 33-gliadin, present high immunogenicity and are responsible for triggering of this disease. Within CD characterization, there are mainly two different approaches to carry out this study; one focuses on its chronic phase, while the other deals with its initial stages. Although the chronic phase of CD has been well characterized, the initiation of the inflammatory process is still unclear. As this process is apparently related to the aggregation of the oligomers involved in CD, the initiation of the disease could be explained by means of clarifying their self-assembly behavior. Thus, this work addresses the clinical explanation, within the chronic approach, attempting to combine it with the physicochemical techniques used for characterization of proteins aggregates as well.

Keywords: Celiac disease, environmental factors, genetic factors, immunologic disease, assembly of 33- gliadin, gliadin, spectroscopic techniques.

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Article Details

Year: 2018
Published on: 07 September, 2018
Page: [1058 - 1070]
Pages: 13
DOI: 10.2174/1389203719666180531123514
Price: $65

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