Synergistic Interaction Between Plant Products and Antibiotics Against Potential Pathogenic Bacteria
Pp. 88-152 (65)
Banasri Hazra, Sutapa Biswas Majee, Subhalakshmi Ghosh and Dhruti Avlani
The emergence of multi-drug resistant pathogenic bacteria, coupled with a
decline in discovery of new drugs, has gradually steered the world to the doorstep of
post-antibiotic era as trivial infections often become untreatable with the existing
antibiotics. Therefore, design and development of new therapeutic strategies would be
of paramount importance, primarily by interfering with mechanisms leading to drug
resistance. Accordingly, researchers are aiming at the restoration of activity of existing
antibiotics by using resistance modifying agents (RMA), and looking for suitable
secondary plant metabolites to function as RMAs.
Plant-derived RMAs are believed to rejuvenate the action of conventional antibiotics
via unique mechanisms, as for example, by acting upon bacterial efflux pumps,
enhancing membrane permeability, and inhibiting the synthesis of proteins responsible
for bacterial resistance. However, due to the lack of adequate pharmacological data,
these phytochemicals are yet to be approved for clinical use, despite the upcoming
prospect of their therapeutic application.
This chapter focuses on the relevant screening strategies to characterise new RMAs
from plant constituents exhibiting resistance modifying activity against pathogenic
bacteria. Also, the respective mode of synergistic interaction of these agents has been
discussed in view of their potential application to supplement the conventional
antibiotics against drug-resistant bacterial infections.
Antimicrobial resistance, Antibiotic adjuvant, Efflux pump inhibitor,
FICI, Isobologram, Plant-derived RMA, Pathogenic bacteria, Phytochemical,
Resistance modifying agent, Synergistic interaction.
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.