Abstract
In the past two decades, the search for novel pharmacotherapies to treat alcohol addiction has been a global endeavor. This has resulted in several drugs that have been approved and successfully marketed for public use while some are still in the testing phase. These pharmacological agents, though effective for the treatment of alcoholism, are not without shortcomings; such as abuse potential, serious mental and physical adverse effects, interaction with alcohol and also poor metabolism and excretion. As more is being understood about the neurobiology of alcohol addiction as well as the unique pharmacological action of these drugs, new agents are evaluated for potential benefits when used as an adjunct in combination therapy. This review article summarizes the novel pharmacotherapeutic approaches used in the treatment of alcohol addiction by focusing on the drugs, which include neramexane, gabapentin, baclofen, aripiprazole, nalmafene, and quetiapine.
Keywords: Alcohol, neramexane, gabapentin, baclofen, aripiprazole, nalmafene, quetiapine.
Current Drug Targets
Title:Novel Pharmacotherapeutic Approaches in Treatment of Alcohol Addiction
Volume: 19 Issue: 12
Author(s): Rashidi Mohamed Pakri Mohamed, Jaya Kumar*, Shihad Udin Ahmad and Isa Naina Mohamed
Affiliation:
- Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, 56000 Cheras, Kuala Lumpur,Malaysia
Keywords: Alcohol, neramexane, gabapentin, baclofen, aripiprazole, nalmafene, quetiapine.
Abstract: In the past two decades, the search for novel pharmacotherapies to treat alcohol addiction has been a global endeavor. This has resulted in several drugs that have been approved and successfully marketed for public use while some are still in the testing phase. These pharmacological agents, though effective for the treatment of alcoholism, are not without shortcomings; such as abuse potential, serious mental and physical adverse effects, interaction with alcohol and also poor metabolism and excretion. As more is being understood about the neurobiology of alcohol addiction as well as the unique pharmacological action of these drugs, new agents are evaluated for potential benefits when used as an adjunct in combination therapy. This review article summarizes the novel pharmacotherapeutic approaches used in the treatment of alcohol addiction by focusing on the drugs, which include neramexane, gabapentin, baclofen, aripiprazole, nalmafene, and quetiapine.
Export Options
About this article
Cite this article as:
Pakri Mohamed Mohamed Rashidi , Kumar Jaya *, Ahmad Udin Shihad and Mohamed Naina Isa , Novel Pharmacotherapeutic Approaches in Treatment of Alcohol Addiction, Current Drug Targets 2018; 19 (12) . https://dx.doi.org/10.2174/1389450119666180523092534
DOI https://dx.doi.org/10.2174/1389450119666180523092534 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Optimal Medical Therapy for Coronary Artery Disease in 2011 – Perspectives from the STICH Trial
Cardiovascular & Hematological Agents in Medicinal Chemistry Transdermal Oxandrolone: Ex Vivo Percutaneous Absorption Study
Current Drug Delivery Gastrointestinal Hemorrhage is Associated with Mortality after Acute Ischemic Stroke
Current Neurovascular Research Recent Advances in Medicinal Chemistry of Sulfonamides. Rational Design as Anti-Tumoral, Anti-Bacterial and Anti-Inflammatory Agents
Mini-Reviews in Medicinal Chemistry Meta-Analysis of Creatine for Neuroprotection Against Parkinson’s Disease
CNS & Neurological Disorders - Drug Targets Discovery of <i>Channa Striata</i> Extracts as Regenerative Medicine in Promoting Wound Healing and Scarless Skin Regeneration
The Natural Products Journal Targeting Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1): Structure-Based Design of MKP-1 Inhibitors and Upregulators
Current Medicinal Chemistry Pharmacogenetics of Bipolar Disorder
Current Pharmacogenomics Prophylaxis of Cancer
Current Cancer Therapy Reviews Synthesis and Antioxidant Properties of Novel Memantine Derivatives
Central Nervous System Agents in Medicinal Chemistry Nasal Polyposis: From Pathogenesis to Treatment, An Update
Inflammation & Allergy - Drug Targets (Discontinued) Actions of the Anti-Angiogenic Compound Angiostatin in an Animal Model of Alzheimer’s Disease
Current Alzheimer Research The Quest for a Tumor Suppressor Gene Phenotype
Current Molecular Medicine Patent Selections
Recent Patents on Drug Delivery & Formulation On Therapeutic Drug Monitoring of Thiopurines in Inflammatory Bowel Disease; Pharmacology, Pharmacogenomics, Drug Intolerance and Clinical Relevance
Current Drug Metabolism Successful Applications of Computer Aided Drug Discovery: Moving Drugs from Concept to the Clinic
Current Topics in Medicinal Chemistry Knee Osteoarthritis and Exercise Adherence: A Review
Current Aging Science Targeted D4 Dopamine Receptors: Implications for Drug Discovery and Therapeutic Development
Current Drug Targets Adaptation to Traumatic Stress: Resilient Traits, Resources, and Trajectories of Outcomes
Current Psychiatry Reviews Understanding Cardiotocography: Technical Aspects
Current Women`s Health Reviews