Polyphenols, their Metabolites and Derivatives as Drug Leads

Author(s): A. Filipa Almeida, Claudia Nunes dos Santos, Maria Rita Ventura*

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 19 , 2018


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Abstract:

In this non-comprehensive review, the potential of natural polyphenols as lead compounds for the design and synthesis of new molecules with potential application in several diseases was highlighted. Organic synthesis has been essential for the development of new analogues of naturally found polyphenols, providing a wide range of structural modifications for structure-activity relationship studies and improving or modulating the biological activity of the promising compounds.

Keywords: Polyphenols, polyphenol metabolites, chemical synthesis, medicinal chemistry, drugs, anticancer.

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Article Details

VOLUME: 24
ISSUE: 19
Year: 2018
Published on: 23 September, 2018
Page: [2188 - 2207]
Pages: 20
DOI: 10.2174/1381612824666180516103609
Price: $65

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