In this non-comprehensive review, the potential of natural polyphenols as lead compounds for the
design and synthesis of new molecules with potential application in several diseases was highlighted. Organic
synthesis has been essential for the development of new analogues of naturally found polyphenols, providing a
wide range of structural modifications for structure-activity relationship studies and improving or modulating the
biological activity of the promising compounds.
Keywords: Polyphenols, polyphenol metabolites, chemical synthesis, medicinal chemistry, drugs, anticancer.
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