Mammalian STE20-like kinase-1 (Mst1) is a generally expressed apoptosis-promoting
kinase and a key bridgebuilder of apoptotic signaling in the etiology of tissue injury. Despite the
fact that the biological function of Mst1 and its role in the cell's signalling network have yet to be
determined, however, there is a lot of evidence that Mst1 plays an important role in cell death which
results from tissue injury. Previous studies have shown that Mst1 is not only a target for some apoptosis-
related molecules such as caspase 3 and P53, but also act as an activator of these proteinases to
magnify apoptosis signal pathways. This article reviews the role of Mst1 in the signaling pathways
which is related with the neuronal cell apoptosis or microglia activation following myocardial and
brain injury. Therefore, this work contributes to better understanding of the pathological process of
myocardial and brain injury.
Keywords: Ischemia-reperfusion injury, ischemic stroke, oxidative stress, Mst1, apopotosis, microglia.
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