Role of Oxidative Stress in Diabetic Retinopathy and the Beneficial Effects of Flavonoids

Author(s): Mohammad Shamsul Ola*, Dalia Al-Dosari, Abdullah S. Alhomida

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 19 , 2018


Become EABM
Become Reviewer
Call for Editor

Abstract:

Diabetic Retinopathy (DR) is one of the leading causes of decreased vision and blindness in developed countries. Diabetes-induced metabolic disorder is believed to increase oxidative stress in the retina. This results in deleterious change through dysregulation of cellular physiology that damages both neuronal and vascular cells. In this review, we first highlight the evidence of potential metabolic sources and pathways which increase oxidative stress that contribute to retinal pathology in diabetes. As oxidative stress is a central factor in the pathophysiology of DR, antioxidants therapy would be beneficial towards preventing the retinal damage. A number of experimental studies by our group and others showed that dietary flavonoids cause reduction in increased oxidative stress and other beneficial effects in diabetic retina. We then discuss the beneficial effects of the six major flavonoid families, such as flavanones, flavanols, flavonols, isoflavones, flavones and anthocyanins, which have been studied to improve retinal damage. Flavanoids, being known antioxidants, may ameliorate the retinal degenerative factors including apoptosis, inflammation and neurodegeneration in diabetes. Therefore, intake of potential dietary flavonoids would limit oxidative stress and thereby prevent the retinal damage, and subsequently the development of DR.

Keywords: Diabetic retinopathy, retina, neurotrophic factor, oxidative stress, flavonoids, apoptosis.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 24
ISSUE: 19
Year: 2018
Published on: 23 September, 2018
Page: [2180 - 2187]
Pages: 8
DOI: 10.2174/1381612824666180515151043
Price: $65

Article Metrics

PDF: 32
HTML: 3