Polyphenols constitute a group of compounds that have been highly investigated for their beneficial
effects against various pathologic and non-pathologic conditions and diseases. Among their multi-faceted properties,
their anti-oxidant potential nominates them as ideal protective candidates for conditions characterized by
elevated levels of oxidative stress, including aging and age-related diseases. The nematode Caenorhabditis elegans
is a multicellular model organism that is highly exploited in studies related to aging and age-associated
pathologies. In this review, we will summarize studies where polyphenolic compounds have been tested for their
anti-aging potential and their protective role against the progression of age-related diseases using C. elegans as
their main model.
Keywords: Aging, senescence, aggregation, age-related diseases, C. elegans, polyphenols, longevity, stress resistance.
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