This chapter explores therapeutic targets and the anti-inflammatory nature of some naturally-
occurring compounds and the current or potential use of these compounds in the treatment of
chronic inflammatory pain states. We will review the mechanisms of chronic inflammatory pain, the
molecular targets of selected natural compounds in inhibiting inflammatory pain, and the traditional
and current approaches to treating pain using these compounds. Previous research on experimental as
well as clinical pain will be summarized from in vitro to animal and human models. Potential areas for
further research will also be discussed.
Keywords: Natural compounds, pain, inflammation, neuropathy, molecular targets, drug development.
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