Title:Recent Advances on Glioblastoma Multiforme and Nano-drug Carriers: A Review
VOLUME: 26 ISSUE: 31
Author(s):Wang Liao, Shengnuo Fan, Yuqiu Zheng, Shaowei Liao , Ying Xiong, Yi Li and Jun Liu *
Affiliation:Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120
Keywords:Glioblastoma multiforme, brain blood barrier, glioblastoma stem cells, nanocarriers, lipids, gold, targeted
therapy.
Abstract:Glioblastoma Multiforme (GBM) is the most frequent glioma with a poor prognosis.
The mainstay treatment for GBM is chemotherapy, but the average survival of GBM remains
unsatisfactory due to therapeutic resistance. Poor permeability restricted by the Blood
Brain Barrier (BBB) and the presence of Glioblastoma Stem Cells (GSCs) remain as two
problems for chemotherapy. Recently, nanocarriers have attracted much attention in the research
of GBM, owing to their advantages in self-assembly, biosafety, release controllability,
and BBB penetrability, making them promising candidates for GBM treatment. This article
aims to review the biologic signatures of BBB and GSCs, as well as the new development of
nano-drug delivery systems to facilitate our understanding of targeted treatment for GBM.