Cartilage, as a nanostructured tissue, because of its awfully poor capacity for inherent regeneration
and complete hierarchical structure, is severely difficult to regenerate after damages. Tissue
engineering methods have provided a great contribution for cartilage repair. Nanomaterials have special
superiority in regulating stem cell behaviors due to their special mechanical and biological properties
and biomimetic characteristics. Therefore, they have been given great attention in tissue regeneration.
Nanomaterials are divided into organic and inorganic nanomaterials. They provide the microenvironment
to support differentiation of stem cells. Nanomaterials inducing stem cells to differentiate into
chondrocyte phenotypes would be a benefit for cartilage tissue regeneration, then promoting the development
of cartilage tissue engineering. In this review, we summarized the important roles of nanomaterials
in chondrogenic differentiation of stem cells.
Keywords: Nanomaterials, stem cells, chondrogenic differentiation, cartilage tissue engineering, nanomaterials.
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