Pharmacological Treatment of Hypertension: Effects in Endothelial Function

Author(s): Leonardo Cobos-Segarra*, Patricio Lopez-Jaramillo, Carlos Ponte-Negretti CI, Raul Villar, Ernesto Penaherrera

Journal Name: Current Hypertension Reviews

Volume 14 , Issue 2 , 2018

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Graphical Abstract:


The vascular endothelium plays an important role to maintain the functional integrity of the cardiovascular system. The synthesis and secretion of substances with biological activity such as prostacyclin and NO give endothelium the vasodilator, antithrombotic, and antiatherosclerotic properties. Endothelial dysfunction participates in the genesis of HTA, but also hypertension produces endothelial damage. The major class of antihypertensive drugs has beneficial effects in the recuperation of the endothelial function, actions that are contributing to explain the impact of the adequate control of HTA in the reduction of CV events.

Keywords: Hypertension, endothelial function, cardiovascular system, biological activity, HTA, antihypertensive drugs.

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Article Details

Year: 2018
Published on: 07 May, 2018
Page: [123 - 127]
Pages: 5
DOI: 10.2174/1573402114666180508104828
Price: $65

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