The progressive supranuclear palsy is a progressive neurodegenerative disease characterized
by Parkinsonism, oculomotor abnormalities, early postural instability and cognitive impairment. Neurodegeneration
in PSP is associated with tau protein, but the mechanisms by which tau abnormalities
lead to cell dysfunction and death are not well understood.
Neuro-behavioural problems related to the fear and loss of autonomy can determinate many bioethical
implications. Careful planning involving patients’ families, academic and industry researchers were necessary
to ensure improvement in quality of life.