Abstract
Background & Objective: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder characterized by hyperactivity, impulsivity and inattention. Children with ADHD have challenges with learning, behavior and psychosocial adjustments, sometimes retained into adulthood. The exact etiology of ADHD is unknown, and the pathophysiology of this disease is complex. Several hypotheses have been raised regarding ADHD pathogenesis, including serotonergic and catecholaminergic signalling pathway dysfunction, neurotropic-related factors, oxidative stress, or neuroinflammation.
Vitamin D has an important protective effect against inflammation, oxidative stress and certain neurotrophic factors and neurotransmitter, as well as facilitating dopaminergic and serotonergic functions. Vitamin D levels in children with ADHD are lower than in healthy children, and thus may be involved in the pathogenesis of ADHD. These observations, therefore, confirm the neuroprotective role of vitamin D through multiple molecular mechanisms and can be considered as a promising target in understanding ADHD pathology.
Conclusion: In this context, the present study reviews the molecular pathways of vitamin D in ADHD patients.
Keywords: Attention-deficit/hyperactivity disorder, vitamin D, oxidative stress, inflammation, neurotrophic factors, neurotransmitters.
CNS & Neurological Disorders - Drug Targets
Title:Vitamin D’s Molecular Action Mechanism in Attention-Deficit/ Hyperactivity Disorder: A Review of Evidence
Volume: 17 Issue: 4
Author(s): Ahmad Saedisomeolia, Mahsa Samadi, Fatemeh Gholami, Marzieh Seyedi, Mohammad Effatpanah, Rezvan Hashemi, Mina Abdolahi and Niyaz Mohammadzadeh Honarvar*
Affiliation:
- Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran,Iran
Keywords: Attention-deficit/hyperactivity disorder, vitamin D, oxidative stress, inflammation, neurotrophic factors, neurotransmitters.
Abstract: Background & Objective: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder characterized by hyperactivity, impulsivity and inattention. Children with ADHD have challenges with learning, behavior and psychosocial adjustments, sometimes retained into adulthood. The exact etiology of ADHD is unknown, and the pathophysiology of this disease is complex. Several hypotheses have been raised regarding ADHD pathogenesis, including serotonergic and catecholaminergic signalling pathway dysfunction, neurotropic-related factors, oxidative stress, or neuroinflammation.
Vitamin D has an important protective effect against inflammation, oxidative stress and certain neurotrophic factors and neurotransmitter, as well as facilitating dopaminergic and serotonergic functions. Vitamin D levels in children with ADHD are lower than in healthy children, and thus may be involved in the pathogenesis of ADHD. These observations, therefore, confirm the neuroprotective role of vitamin D through multiple molecular mechanisms and can be considered as a promising target in understanding ADHD pathology.
Conclusion: In this context, the present study reviews the molecular pathways of vitamin D in ADHD patients.
Export Options
About this article
Cite this article as:
Saedisomeolia Ahmad , Samadi Mahsa , Gholami Fatemeh , Seyedi Marzieh , Effatpanah Mohammad , Hashemi Rezvan , Abdolahi Mina and Honarvar Mohammadzadeh Niyaz *, Vitamin D’s Molecular Action Mechanism in Attention-Deficit/ Hyperactivity Disorder: A Review of Evidence, CNS & Neurological Disorders - Drug Targets 2018; 17 (4) . https://dx.doi.org/10.2174/1871527317666180501111627
DOI https://dx.doi.org/10.2174/1871527317666180501111627 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Coadunation of Biological and Mathematical Perspectives on the Pandemic COVID-19: A Review
Coronaviruses Multiple Sclerosis: Current and Future Treatment Options
Endocrine, Metabolic & Immune Disorders - Drug Targets Importance of Dietary Supplements to the Health
Current Nutrition & Food Science Ion Channel Screening Technology
CNS & Neurological Disorders - Drug Targets The Role of Iron Chelation in Cancer Therapy
Current Medicinal Chemistry Adverse Drug Reactions and Safety Considerations of NSAIDs: Clinical Analysis
Current Drug Safety Green Tea, A Medicinal Food with Promising Neurological Benefits
Current Neuropharmacology Why Some Messages Speak Better: Child Immunization in the News and on the Internet
Current Drug Safety The Role of T and B Cells in Atherosclerosis: Potential Clinical Implications
Current Pharmaceutical Design Heregulin in Breast Cancer: Old Story, New Paradigm
Current Pharmaceutical Design Impact of Anabolic Androgenic Steroids on Neuropeptide Systems
Mini-Reviews in Medicinal Chemistry Neuronal High-Affinity Sodium-Dependent Glutamate Transporters (EAATs): Targets for the Development of Novel Therapeutics Against Neurodegenerative Diseases
Current Pharmaceutical Design Electrochemical MIP-Sensors for Drugs
Current Medicinal Chemistry Computational Models for Central Nervous System Penetration
Current Computer-Aided Drug Design Metabolism and the Paradoxical Effects of Arsenic: Carcinogenesis and Anticancer
Current Medicinal Chemistry The Association of ACT -17 A/T Polymorphism with Alzheimer’s Disease: A Meta-Analysis
Current Alzheimer Research Diagnostic and Therapeutic Use of Human Recombinant Thyrotropin (rhTSH)(Thyrogen®) in Well-Differentiated Thyroid Cancer - Current Indications and Future Perspectives - A Review
Current Pharmaceutical Analysis The Physiological Relevance of Protein Phosphatase 1 and its Interacting Proteins to Health and Disease
Current Medicinal Chemistry Deciphering the Neuroprotective Role of Glucagon-like Peptide-1 Agonists in Diabetic Neuropathy: Current Perspective and Future Directions
Current Protein & Peptide Science General Aspects of Metal Toxicity
Current Medicinal Chemistry