Vitamin D’s Molecular Action Mechanism in Attention-Deficit/ Hyperactivity Disorder: A Review of Evidence

Author(s): Ahmad Saedisomeolia, Mahsa Samadi, Fatemeh Gholami, Marzieh Seyedi, Mohammad Effatpanah, Rezvan Hashemi, Mina Abdolahi, Niyaz Mohammadzadeh Honarvar*

Journal Name: CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 17 , Issue 4 , 2018

Become EABM
Become Reviewer

Graphical Abstract:


Background & Objective: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder characterized by hyperactivity, impulsivity and inattention. Children with ADHD have challenges with learning, behavior and psychosocial adjustments, sometimes retained into adulthood. The exact etiology of ADHD is unknown, and the pathophysiology of this disease is complex. Several hypotheses have been raised regarding ADHD pathogenesis, including serotonergic and catecholaminergic signalling pathway dysfunction, neurotropic-related factors, oxidative stress, or neuroinflammation.

Vitamin D has an important protective effect against inflammation, oxidative stress and certain neurotrophic factors and neurotransmitter, as well as facilitating dopaminergic and serotonergic functions. Vitamin D levels in children with ADHD are lower than in healthy children, and thus may be involved in the pathogenesis of ADHD. These observations, therefore, confirm the neuroprotective role of vitamin D through multiple molecular mechanisms and can be considered as a promising target in understanding ADHD pathology.

Conclusion: In this context, the present study reviews the molecular pathways of vitamin D in ADHD patients.

Keywords: Attention-deficit/hyperactivity disorder, vitamin D, oxidative stress, inflammation, neurotrophic factors, neurotransmitters.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2018
Page: [280 - 290]
Pages: 11
DOI: 10.2174/1871527317666180501111627
Price: $65

Article Metrics

PDF: 56