Advances and Application of DNA-functionalized Nanoparticles

Author(s): Xun Zhang, Fei Wang, Jin-Liang Sheng*, Min-Xuan Sun*.

Journal Name: Current Medicinal Chemistry

Volume 26 , Issue 40 , 2019

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Abstract:

DNA-functionalized nanoparticle (DfNP) technology, the integration of DNA with nanotechnology, has emerged over recent decades as a promising biofunctionalization tool in the light of biotechnological approaches. The development of DfNPs has exhibited significant potential for several biological and biomedical applications. In this review, we focus on the mechanism of a series of DNA-NP nanocomposites and highlight the superstructures of DNA-based NPs. We also summarize the applications of these nanocomposites in cell imaging, cancer therapy and bioanalytical detection.

Keywords: DNA, nanoparticle, cancer therapy and imaging, bioanalysis, biofunctionalization, biomedical applications.

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