Copper-Based Bulk and Nano-Catalysts for the One-Pot Propargylamine Synthesis

Author(s): Soheil Sayyahi*, Seyyed Jafar Saghanezhad

Journal Name: Mini-Reviews in Organic Chemistry

Volume 16 , Issue 4 , 2019

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Graphical Abstract:


Propargylamines are prominent components strikethrough as precursors for the synthesis of miscellaneous nitrogen-containing compounds, such as allylamines, pyrrolidines, pyrroles and oxazoles or as intermediates in the preparation of a various natural product, biologically active and pharmaceutical compounds. The catalytic coupling of the aldehyde–alkyne–amine (A3 coupling) has shown great utility in the simple and rapid preparation of propargylamines in broadly tolerant and highly tunable reaction conditions. In this respect, various catalytic systems using transition metal catalysts have been developed. Based on a literature survey, Cu catalysts have promoted this field substantially via development of new methods for the synthesis of propargylamines. This review will cover copper-based catalyst system reported for the synthesis of propargylamine derivatives until 2017.

Keywords: Multicomponent Reactions, propargylamine, A3 coupling, copper-based catalyst, bulk catalyst, nanocatalysts.

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Article Details

Year: 2019
Published on: 19 March, 2019
Page: [361 - 368]
Pages: 8
DOI: 10.2174/1570193X15666180430151658
Price: $65

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