This mini-review will describe the recent applications of tert–butyl nitrite
(TBN) in organic synthesis. Due to its unique structural feature and wide application,
TBN holds a prominent and great potential in organic synthesis. Since the applications of
TBN is too wide and developments have been too fast, Part-I of the present mini-review has
surveyed the studies carried out to date in three areas viz. aerobic oxidation, annulation, and diazotization,
which is demonstrated by the work outlined in this mini-review. The mechanisms of
these transformations will be briefly described in this mini-review. TBN has been utilized in
other organic transformations, such as nitrogenation, nitrification, nitrosylation, multifunctionalization,
nitrodecarbocyclization, nitro-aminoxylation and etc. which will be presented as part-
II in mid-2018.
Keywords: tert-Butyl nitrite, organic synthesis, aerobic oxidation, annulation, diazotization, mechanism.
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