Natural Macromolecules with Protective and Antitumor Activity

Author(s): Cioanca Oana, Trifan Adriana, Cornelia Mircea*, Scripcariu Dragos, Hancianu Monica

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 18 , Issue 5 , 2018

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Graphical Abstract:


This review summarizes the literature data regarding plant lectins as novel drug sources in the prevention or treatment of cancer. Moreover, such compounds have been described as natural toxins that possess different biological activities (cytotoxic, antitumor, antimutagenic and anticarcinogenic properties). This activity depends greatly on their structure and affinity. Most of the mushroom heterosides are known as β-glucans with β-(1→3)-glycosidic bonds. It is thought that their conformation, bonds, molecular size can modulate the immune response by triggering different receptors. The mechanism on normal and tumor cells of various plant and mushroom polysaccharides and lectins is briefly presented in this paper.

Keywords: Cancer, plant lectins, mushroom, mechanism, apoptosis, receptors.

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Article Details

Year: 2018
Page: [675 - 683]
Pages: 9
DOI: 10.2174/1871520618666180425115029
Price: $65

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PDF: 46
PRC: 1