Background and Objective: Intranasal drug delivery, being non-invasive in nature has
turned out to be a promising option for drug administration. It is particularly valuable for drugs having
low oral bioavailability due to degradation in Gastrointestinal Tract (GIT).
Discussion: Nasal route provides a unique micro-environment due to absence of deactivating enzymes
and abundant vascular tissues which bring about direct systemic display, along with these lines abstaining
the first pass hepatic metabolism.
Conclusion: The present article provides in-depth information about the physicochemical parameters
associated with drug absorption in nasal mucosa and factors influencing it. The pathways and mechanisms
associated with nasal drug uptake alongside current pharmaceutical applications are additionally
Keywords: Brain-targeting, ciliary movement, desposition, factors influencing absorption, intranasal drug delivery, local delivery,
nasal drug absorption, systemic delivery.
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