Abstract
Background and Objective: Intranasal drug delivery, being non-invasive in nature has turned out to be a promising option for drug administration. It is particularly valuable for drugs having low oral bioavailability due to degradation in Gastrointestinal Tract (GIT).
Discussion: Nasal route provides a unique micro-environment due to absence of deactivating enzymes and abundant vascular tissues which bring about direct systemic display, along with these lines abstaining the first pass hepatic metabolism.
Conclusion: The present article provides in-depth information about the physicochemical parameters associated with drug absorption in nasal mucosa and factors influencing it. The pathways and mechanisms associated with nasal drug uptake alongside current pharmaceutical applications are additionally summarized.
Keywords: Brain-targeting, ciliary movement, desposition, factors influencing absorption, intranasal drug delivery, local delivery, nasal drug absorption, systemic delivery.
Drug Delivery Letters
Title:Medication Conveyance Through Nose: Factors Affecting and Novel Applications
Volume: 8 Issue: 3
Author(s): Jaimini Gandhi*, Nimeet Desai, Pooja Golwala and Pranav Shah
Affiliation:
- Department of Pharmaceutics, Maliba Pharmacy College, UKA Tarsadia University, Maliba Campus, Bardoli- 396401, Surat, Gujarat,India
Keywords: Brain-targeting, ciliary movement, desposition, factors influencing absorption, intranasal drug delivery, local delivery, nasal drug absorption, systemic delivery.
Abstract: Background and Objective: Intranasal drug delivery, being non-invasive in nature has turned out to be a promising option for drug administration. It is particularly valuable for drugs having low oral bioavailability due to degradation in Gastrointestinal Tract (GIT).
Discussion: Nasal route provides a unique micro-environment due to absence of deactivating enzymes and abundant vascular tissues which bring about direct systemic display, along with these lines abstaining the first pass hepatic metabolism.
Conclusion: The present article provides in-depth information about the physicochemical parameters associated with drug absorption in nasal mucosa and factors influencing it. The pathways and mechanisms associated with nasal drug uptake alongside current pharmaceutical applications are additionally summarized.
Export Options
About this article
Cite this article as:
Gandhi Jaimini*, Desai Nimeet, Golwala Pooja and Shah Pranav, Medication Conveyance Through Nose: Factors Affecting and Novel Applications, Drug Delivery Letters 2018; 8 (3) . https://dx.doi.org/10.2174/2210303108666180423165814
DOI https://dx.doi.org/10.2174/2210303108666180423165814 |
Print ISSN 2210-3031 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-304X |
Call for Papers in Thematic Issues
Nanomaterial Assisted Targeted Therapies for Chronic Disorders- Preclinical to Clinical Outcomes
In recent years, the integration of nanomaterials into therapeutic strategies has emerged as a promising avenue in the pursuit of more effective treatments for chronic disorders. This dynamic field, explored in the context of "Nanomaterial Assisted Targeted Therapies for Chronic Disorders - Preclinical to Clinical Outcomes," seeks to bridge the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data
Current Drug Targets Quantum Dots and Their Clinical Applications
Nanoscience & Nanotechnology-Asia Mammary Development and Breast Cancer: The Role of Stem Cells
Current Molecular Medicine Prostate Cancer Horizons in the Development of Novel Anti-Cancer Strategies
Current Medicinal Chemistry - Anti-Cancer Agents Epigenome-Wide Association Studies (EWAS) in Cancer
Current Genomics Editorial [Hot Topic: ADAMs: Targets for Drug Discovery (Executive Editor: Marcia L. Moss)]
Current Pharmaceutical Design New Insights in the Gene Electrotransfer Process: Evidence for the Involvement of the Plasmid DNA Topology
Current Gene Therapy Regulation of p53 Activity
Current Chemical Biology Recent Advances on Small-Molecule Survivin Inhibitors
Current Medicinal Chemistry Recent Developments in Protein and Cell-Targeted Aptamer Selection and Applications
Current Medicinal Chemistry Rho GTPase Effector Functions in Tumor Cell Invasion and Metastasis
Current Drug Targets Efficacy and Safety of Targeting Androgen Receptor in Advanced Breast Cancer: A Systematic Review
Current Cancer Therapy Reviews Regulation of Intestinal Barrier Function by Dietary Polyphenols
Current Nutrition & Food Science Rho Kinase Inhibitors: Potential Treatments for Diabetes and Diabetic Complications
Current Pharmaceutical Design Novel Hybrid Molecules of Isoxazole Chalcone Derivatives: Synthesis and Study of in vitro Cytotoxic Activities
Letters in Drug Design & Discovery Leptin as a Cardiac Pro-Hypertrophic Factor and its Potential Role in the Development of Heart Failure
Current Pharmaceutical Design Preface: “The Whole is Greater Than the Sum of its Parts.” - Aristotle
Current Metabolomics Developments in the Application of 1,2,3-Triazoles in Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery The Novel Functions of cGMP-Specific Phosphodiesterase 5 and its Inhibitors in Carcinoma Cells and Pulmonary/Cardiovascular Vessels
Current Topics in Medicinal Chemistry Clinical Approaches Toward Tumor Angiogenesis: Past, Present and Future
Current Pharmaceutical Design