Role of Inflammatory Markers in Elderly Type 2 Diabetic Patients with Mild Cognitive Impairment

Author(s): Salwa S. Hosny, Ahmed M. Bahaaeldin*, Mohamed S. Khater, Meram M. Bekhet, Hayam A. Hebah, Ghada A. Hasanin

Journal Name: Current Diabetes Reviews

Volume 15 , Issue 3 , 2019

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Background: Type 2 diabetes (T2DM) is a risk factor for Alzheimer’s disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated.

Objectives: To determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI).

Methods: Our study was conducted on 90 elderly subjects (aged 60 years old or more). They were divided into Group І, 30 patients with T2DM and mild cognitive impairment, group ІІ, 30 patients with T2DM without cognitive impairment and group III, 30 healthy subjects as a control group. They were subjected to history taking, full clinical examination, anthropometric measurement, the Addenbrooke’s Cognitive Examination III (ACE---III 2012), Fasting plasma glucose, 2 hours plasma glucose, HbA1c, lipid profile, protein/creatinine ratio, serum sVCAM-1 and hs-CRP.

Results: Serum levels of sVCAM-1 in diabetic elderly patients with MCI were significantly higher (946.7 ± 162.01 ng/ml) than diabetic elderly patients without cognitive impairment (479.06 ± 65.27 ng/ml) and control (263.7 ± 72.05 ng/ml) with (P=0.002). Serum levels of Hs-CRP in diabetic elderly patients with MCI were significantly higher than as diabetic elderly patients without cognitive impairment and control with (P=0.005).

Conclusion: Elderly diabetic patients with mild cognitive impairment have higher levels of soluble adhesion molecules and markers of low-grade systemic inflammation than other groups.

Keywords: Diabetes mellitus, highly sensitive c-reactive protein, soluble vascular adhesion molecule, mild cognitive impairment, elderly, inflammatory markers.

Petersen RC. Mild cognitive impairment. N Engl J Med 2011; 364(23): 2227-34.
Plassman Bl, Langa KM, Fisher GG, et al. Prevalence of cognitive impairment without dementia in the United States. Ann Intern Med 2008; 148: 427-34.
Strachan MW, Reynolds RM, Marioni RE, Price JF. Cognitive function, dementia and type 2 diabetes mellitus in the elderly. Nat Rev Endocrinol 2011; 7(2): 108-14.
Kumar V, Fausto N, Abbas AK, Aster JC. Robbins and Cotran Pathologic Basis of Disease 2015.
Hermida AP, McDonald WM, Steenland K, Levey A. The association between late-life depression, mild cognitive impairment and dementia: is inflammation the missing link? Expert Rev Neurother 2012; 12(11): 1339-50.
Ribeiro DR, Ramos AM, Vieira PL, et al. High-sensitivity C-reactive protein as a predictor of cardiovascular events after ST-elevation myocardial infarction. Arq Bras Cardiol 2014; 103(1): 69-75.
Cook-Mills JM, Marchese ME, Abdala-Valencia H. Vascular cell adhesion molecule-1 expression and signaling during disease: regulation by reactive oxygen species and antioxidants. Antioxid Redox Signal 2011; 15(6): 1607-38.
Novak V, Zhao P, Manor B, et al. Adhesion molecules, altered vaso-reactivity, and brain atrophy in type 2 diabetes. Diabetes Care 2011; 34(11): 2438-41.
Elhadd TA, Kennedy G, Robb R, McLaren M, Jung RT, Belch JJ. Elevated soluble cell adhesion molecules E-selectin and intercellular cell adhesion molecule-1 in type- 2 diabetic patients with and without asymptomatic peripheral arterial disease. Int Angiol 2014; 23(2): 128-33.
Meredith IT, Hope SA. Cellular adhesion molecules and cardiovascular disease. Part II. Their association with conventional and emerging risk factors, acute coronary events and cardiovascular risk prediction. Int Med J 2003; 33(9-10): 450-62.
Ding J, Strachan MWJ, Reynolds RM, et al. Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: The Edinburgh type 2 diabetes study. Diabetes 2010; 59(11): 2883-9.
Boulbou MS, Koukoulis GN, Vasiou KG, Petinaki EA, Gourgoulianis KI, Fezoulidis IB. Increased soluble E selectin levels in type 2 diabetic patients with peripheral arterial disease. Int Angiol 2014; 23(1): 18-24.
Anna B, Maciej C, Jerzy L, Malgorzata SW, Malgorzata GC. Serum levels of inflammatory markers in depressed elderly patients with diabetes and mild cognitive impairment. PLoS One 2015; 10(3): e0120433.
Malgorzata GC, Malgorzata SW, Jerzy L, Anna B, Maciej C. Serum soluble adhesion molecules and markers of systemic inflammation in elderly diabetic patients with mild cognitive impairment and depressive symptoms. BioMed Res Int 2015; 826180.
Jerzy L, Lawlor BA, Abbas Abul K, et al. Cognitive impairment and adhesive molecules 2015; 9: 321-0.

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Article Details

Year: 2019
Page: [247 - 253]
Pages: 7
DOI: 10.2174/1573399814666180423113341
Price: $65

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