Synthetic Approaches of Pyrazolyl Quinolines

Author(s): Rizk E. Khidre*, Ibrahim Ali M. Radini, Diaa A. Ibrahim

Journal Name: Mini-Reviews in Organic Chemistry

Volume 16 , Issue 4 , 2019

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Graphical Abstract:


This review article represents a survey of the synthetic strategies leading to pyrazolyl quinolines. The synthetic methods are divided into two main groups based on the type of starting reagents: 1) From quinoline ring onto a pyrazole scaffold, 2) From pyrazole ring onto a quinoline scaffold. Also, some medical applications of pyrazolyl quinoline derivatives are mentioned such as anticancer, cell proliferative disorder, glucose transport inhibitors, anti-inflammatory, and inhibitors of leukotriene production for the treatment of cardiovascular. The main purpose of this review is to present a survey of the literature on the synthetic approaches of pyrazolyl quinolines and provide useful and up-to-date data for organic and medicinal chemist since such compound has not been previously reviewed.

Keywords: Pyrazole, quinoline, pyrazolyl quinolones, heterocyclic compounds, carbaldehyde, pyrazole ring.

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Article Details

Year: 2019
Published on: 19 March, 2019
Page: [353 - 360]
Pages: 8
DOI: 10.2174/1570193X15666180419142511
Price: $65

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