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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Review Article

(Diacetoxyiodo)Benzene Mediated Fused 1,2,4-Triazole Derivatives: Synthetic and Medicinal Perspective

Author(s): Vinod Kumar*, Mohit Kumar and Sunil Kumar

Volume 16, Issue 1, 2019

Page: [12 - 25] Pages: 14

DOI: 10.2174/1570193X15666180406142116

Price: $65

Abstract

Hypervalent iodine(III) reagents are well known for the mild and highly selective oxidative chemical transformations, specifically in synthesis of a variety of heterocycles, in a facile and environmentally friendly manner. In past decades, triazole derivatives have gained much attention of the scientific community as some of the products containing triazole moiety contribute towards the development of effective chemotherapeutics. (Diacetoxyiodo)benzene, a hypervalent iodine(III) reagent has proven its significant role in synthesis of 1,2,4-triazoles, in particular, fused derivatives. This review highlights the (Diacetoxyiodo)benzene mediated developments made for the synthesis of fused 1,2,4-triazole derivatives till date. In addition, medicinal perspective of these heterocycles has also been summarized.

Keywords: T-shape geometry, 1, 2, 4-triazole, hypervalent iodine(III) reagent, (diacetoxyiodo)benzene (DIB), biological significance, monosubstituted hydrazines.

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