Background: Cancer is a complicated genetic disorder which is a major global health
issue. The complexities of several cancer therapies are due to heterogenic nature of tumor and its
microenvironment that is highly inflammatory and acidic. Thus, cancer related inflammation
(CRI) is responsible for metastasis, resistance and recurrence of cancer. Although, several
researches are being investigated, still emphasis is being made extensively on targeting the acidic
and heterogenic inflammatory conditions in the tumor microenvironment. The present review article
has focused on the different aspects of cancer to advanced strategies in cancer therapy.
Objective: The review majorly focused on several molecules that are reported for preliminary,
preclinical and clinical trials. Some important aspects are discussed in detail.
Method: Several research findings were carefully reviewed and the conclusion made is based on
the strong evidences that have been reported. Exclusively, the molecules targeting cellular
signalling pathways of the different compartments of tumor microenvironment and inflammatory
state are also reported.
Results: Based on the strong evidences, we were able to document few molecules of natural and
synthetic origin for cancer therapy targeting an important aspect of cancer. In this review, we have
focused on the molecules that target the important cellular signalling pathways especially with respect
to photodynamic and multi-targeted therapies that are in preliminary, preclinical and clinical
Conclusion: Although, the advanced cancer therapeutics have been established but the combination
of different strategies is very important. The efficiency of the treatments depends on the stage
of cancer and response of patients. Search for closely defined and selective molecular targets for a
particular therapy is very complicated due to heterogenic nature of tumor environment, different
therapeutic agents, incubation time, exposure doses and selectivity of therapy. The most promising
photodynamic therapy (PDT) and multi- targeted therapies are being established but the question
whether the cellular proteins that are most susceptible to the therapies has to be addressed. An important
aspect that needs to be addressed is whether cancer is vulnerable to the particular therapy
that selectively induces cell death in the cancerous tissue and inflammatory cells in tumor microenvironment
that is a very challenging aspect of research in cancer treatment strategies. Hence, in
this review, we focused on different therapeutic strategies for targeting multi- components of the
fumigating inflammatory tumor environment.