Diversity Oriented Synthesis of 4H-Pyrimido[2,1-b]benzothiazole Derivatives via Biginellis Reaction: A Review

Author(s): Divyani Gandhi, Priyanka Kalal, Prakash Prajapat, Dinesh Kumar Agarwal, Shikha Agarwal*

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 21 , Issue 4 , 2018

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Background: Heterocycles have extended into widespread use for generating large collection of molecules in multi-component reactions. The development of new strategies for fused pyrimidobenzothiazole system has remained a highly attractive but challenging proposition for scientists working all around.

Objective: The main objective of this work is to explore the utility of different catalysts as an ecofriendly reaction medium for green Biginellis reaction.

Method: A detailed study of Biginellis reactions using various catalysts was done using different research tools. The methods involved reaction of equimolar mixture of benzothiazole, 1,3-diketone and aldehyde as reactants by conventional and greener pathways via Knoevenagal condensation.

Results: The present review has several significant advantages for the scientists regarding green synthesis viz. green conditions, short reaction times, high yields, clean reaction conditions, easy isolation of products, simple work-up procedure and mild reaction conditions.

Conclusion: Our report gives an overview of the combinatorial libraries for fused benzothiazole entities using metal catalyst, acid catalyst, ionic liquids, phase transfer catalyst, nano catalyst, etc.

Keywords: 2-Aminobenzothiazole, fused pyrimidobenzothiazole, Biginellis reaction, substituted benzaldehyde, 1, 3-diketone, multicomponent one pot green synthesis.

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Article Details

Year: 2018
Published on: 25 May, 2018
Page: [236 - 253]
Pages: 18
DOI: 10.2174/1386207321666180330170456
Price: $65

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