Background: Heterocycles have extended into widespread use for generating large
collection of molecules in multi-component reactions. The development of new strategies for fused
pyrimidobenzothiazole system has remained a highly attractive but challenging proposition for
scientists working all around.
Objective: The main objective of this work is to explore the utility of different catalysts as an ecofriendly
reaction medium for green Biginellis reaction.
Method: A detailed study of Biginellis reactions using various catalysts was done using different
research tools. The methods involved reaction of equimolar mixture of benzothiazole, 1,3-diketone
and aldehyde as reactants by conventional and greener pathways via Knoevenagal condensation.
Results: The present review has several significant advantages for the scientists regarding green
synthesis viz. green conditions, short reaction times, high yields, clean reaction conditions, easy
isolation of products, simple work-up procedure and mild reaction conditions.
Conclusion: Our report gives an overview of the combinatorial libraries for fused benzothiazole
entities using metal catalyst, acid catalyst, ionic liquids, phase transfer catalyst, nano catalyst, etc.