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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

Phosphine-free Direct Conversion of Carboxylic Acids into Acyl Isothiocyanates Using Various Electrophilic Halogenation Reagents

Author(s): Aslan Khaje-Kolaki and Babak Mokhtari*

Volume 15, Issue 9, 2018

Page: [805 - 808] Pages: 4

DOI: 10.2174/1570178615666180330155606

Price: $65

Abstract

In this study, the efficiency of some electrophilic halogen reagents including 2,4,6-trichloro- 1,3,5-triazine, 2,4,4,6-tetrabromo-2,5-cyclohexadienone, 2-chloro-1-methylpyridinium iodide, Nbromosuccinimide, trichloroisocyanuric acid, and 1,3-dibromo-5,5-dimethylhydantoin for the direct phosphine-free conversion of carboxylic acids into the corresponding acyl isothiocyanates was investigated. All of the reagents work well for this transformation, but, the best results were obtained when cyanuric chloride in the presence of pyridine was used at room temperature.

Keywords: Acyl isothiocyanate, carboxylic acid, electrophilic halogen, phosphine-free, drugs, HCl.

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