Title:Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Years
VOLUME: 18 ISSUE: 2
Author(s):Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*
Affiliation:Laboratorio de Diversidade Molecular e Quimica Medicinal (LaDMol-QM, Molecular Diversity and Medicinal Chemistry Laboratory), Departament of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropedica, Rio de Janeiro, 239897-000, Laboratorio de Diversidade Molecular e Quimica Medicinal (LaDMol-QM, Molecular Diversity and Medicinal Chemistry Laboratory), Departament of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropedica, Rio de Janeiro, 239897-000, Laboratorio de Diversidade Molecular e Quimica Medicinal (LaDMol-QM, Molecular Diversity and Medicinal Chemistry Laboratory), Departament of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropedica, Rio de Janeiro, 239897-000, Laboratorio de Diversidade Molecular e Quimica Medicinal (LaDMol-QM, Molecular Diversity and Medicinal Chemistry Laboratory), Departament of Chemistry, Universidade Federal Rural do Rio de Janeiro, Seropedica, Rio de Janeiro, 239897-000
Keywords:Coumarins, biological activity, fluorescent sensors, structure–activity relationship, fungi, enzymes.
Abstract:Coumarins are natural products characterized as 1,2 benzopyrones widely distributed in
plants, as well as, in many species of fungi and bacteria. Nowadays, many synthetic procedures allow
the discovery of coumarins with expanded chemical space. The ability to exert noncovalent interactions
with many enzymes and receptors in live organisms lead the coumarins to exhibit a wide range of biological
activities and applications. Then, this manuscript provides an overview of the use of coumarins
compounds in medicinal chemistry in treating many diseases. Important examples of the last years have
been selected concerning the activities of coumarins as anticoagulant, anticancer, antioxidant, antiviral,
anti-diabetics, anti-inflammatory, antibacterial, antifungal and anti-neurodegerative agents. Additionally,
it also includes applications of coumarins as fluorescent sensors for biological systems. Thus, this work
aims to contribute to the development of new rational research projects for the treatment and diagnosis
of pathologies using coumarin derivatives.
