A Review on Camptothecin Analogs with Promising Cytotoxic Profile

Author(s): Sk. Abdul Amin, Nilanjan Adhikari, Tarun Jha*, Shovanlal Gayen*

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 18 , Issue 13 , 2018

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Graphical Abstract:


Camptothecin (CPT), obtained from Camptotheca acuminata (Nyssaceae), is a quinoline type of alkaloid. Apart from various traditional uses, it is mainly used as a potential cytotoxic agent acting against a variety of cancer cell lines. Though searches have been continued for last six decades, still it is a demanding task to design potent and cytotoxic CPTs. Different CPT analogs are synthesized to enhance the cytotoxic potential as well as to increase the pharmacokinetic properties of these analogs. Some of these analogs were proven to be clinically effective in different cancer cell lines. In this article, different CPT analogs have been highlighted extensively to get a detail insight about the structure-property relationships as well as different quantitative structure-activity relationships (QSARs) modeling of these analogs are also discussed. This study may be beneficial for designing newer CPT analogs in future.

Keywords: Camptothecin, homocamptothecin, topoisomerase, cytotoxicity, cancer cell lines, structure-activity relationship, quantitative structure-activity relationship.

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Article Details

Year: 2018
Page: [1796 - 1814]
Pages: 19
DOI: 10.2174/1871520618666180327140956
Price: $65

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