Multicomponent One-pot Synthesis of Substituted 4H-pyrimido [2,1-b] [1,3] Benzothiazole Curcumin Derivatives and Their Antimicrobial Evaluation

Author(s): Shikha Agarwal, Dinesh Kr. Agarwal*, Divyani Gandhi, Kshamta Goyal, Pradeep Goyal

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 10 , 2018

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Abstract:

A novel series of ten substituted 4H-pyrimido [2,1-b] [1,3] benzothiazole curcumin derivatives have been synthesized and evaluated for their antimicrobial activity against Gram positive and Gram negative bacteria viz. Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus and against fungi viz. Alternaria solani, Aspergillus niger, Fusarium culmorum and Rhizopus stolonifer. The mechanism involves condensation of substituted benzaldehyde and curcumin via Knovenegal reaction which further reacts with substituted benzothiazole through Michael addition in the presence of pyridine catalyst using methanol as a solvent. The synthesized compounds were analyzed by elemental and spectral analysis.

Keywords: Curcumin, benzothiazole, multicomponent reaction, 4H-pyrimido[2, 1-b][1, 3] benzothiazole curcumin, antimicrobial activity, bacteria.

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Article Details

VOLUME: 15
ISSUE: 10
Year: 2018
Page: [863 - 869]
Pages: 7
DOI: 10.2174/1570178615666180326161710
Price: $65

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