Background: Oxidative stress and inflammation are important processes involved in
cardiovascular disease. Antioxidant agents, like drugs or natural products from plants or plant-based
food, represent a promising approach to treat these pathologies.
Methods: In light of this, a gemfibrozil-stilbene hybrid (GEM-STIL) was synthesized as a strategy
to combine the well-known antioxidant activity of stilbenes with the reported antioxidant and antiinflammatory
actions of fibrates such as gemfibrozil. The physicochemical properties, including
aqueous solubility, partition coefficient, chemical stability and enzymatic hydrolysis of GEM-STIL
have been studied and indicated that it is stable and has a good lipophilicity. The biological activity
was also evaluated for its effect on C2C12 cell line viability and antioxidant activities.
Results: The results indicated that GEM-STIL was well tolerated and induced a reduction of cell
viability only at higher concentration (100 µg/ml). On the other hand, also at lower nontoxic concentrations
(5, 25 and 50 µg/ml) exhibited a significant reduction of ROS production as well as a
protective effect against the induced oxidative stimulus.
Conclusion: These findings suggest that GEM-STIL is a potential new antioxidant agent useful in
oxidative stress-related pathologies.