2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview

Author(s): Pramod Singh*, Jitendra Singh, Geeta J. Pant*, Mohan S.M. Rawat

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 18 , Issue 10 , 2018

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Nitrogen-containing five-membered heterocyclics play a vital role in pharmaceuticals as well as medicinal chemistry. Pyrazolines play a significant role among other heterocycles because of their therapeutic and pharmacological properties. 2-Pyrazolines displayed a wide variety of biological activities such as anticancer, antiepileptic, anti-aids, antimalarial, insecticidal, antitubercular, etc. and they are used as pesticides, herbicides, fungicides and also used in agrochemical research and analytical chemistry. 2-Pyrazolines are well-known brightening agents used in chemosensor. They have excellent fluorescent properties and are widely used in synthetic fibers, dyes, photography and hole transporting materials. A number of preparation methods of pyrazolines have also been investigated by several research groups. In this review, most of the synthesized and reported nitrogen-containing five-membered heterocycles including 2-pyrazolines, their pharmaceutical evaluation and structure-reactivity are discussed.

Keywords: Biological activities, brightening agents, chalcones, fluorescence, heterocycles, 2-pyrazolines.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2018
Published on: 23 January, 2019
Page: [1366 - 1385]
Pages: 20
DOI: 10.2174/1871520618666180313153407
Price: $65

Article Metrics

PDF: 54
PRC: 3