The pharmacological targeting of microcirculatory dysregulations is a therapeutic strategy
for the treatment of numerous pathological conditions, such as cancer, thrombosis and inflammation. A
promising candidate for this purpose is indole-3-carbinol (I3C), a phytochemical compound of cruciferous
vegetables, and its main derivate 3,3,’-diindolylmethane (DIM). As summarized in this review,
I3C and DIM affect multiple molecular and cellular processes within the microcirculation due to
their pleiotropic action profile. These include angiogenesis, leukocyte-endothelial cell interaction, cytokine
and reactive oxygen species (ROS) production, thrombus formation and microvascular leakage.
Hence, I3C may serve as a lead compound for the future chemical synthesis of novel drugs that exert
comparable beneficial effects while exhibiting an improved bioavailability.