Leishmaniasis and Chagas disease are endemic pathologies in tropical countries. These cause
high morbidity and a public health problem. Current chemotherapies are based on conventional drugs
with variable efficacy and toxicity related with the length of therapeutic schemes and high doses. When
two pharmacological agents are combined into a single molecule, the result is the so-called hybrid molecule.
In the search for new treatments against Chagas disease and leishmaniasis, several studies have
shown that hybrid molecules display high antiprotozoal activity and this emerging strategy is quite
promising in the field of new drug discovery and development. This review focuses on the antiprotozoal
activity of different hybrids obtained from the hybridization of pharmacophores, showing that the most
of the efforts have been concentrated in the molecular hybridization of quinoline, chalcone and hydrazone
Keywords: Medicinal chemistry, antiprotozoal, hybrid, leishmaniosis, organic chemistry, trypanosomiasis.
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