Closed-loop Neuropharmacology for Epilepsy: Distant Dream or Future Reality?

Author(s): Irene Aicua-Rapun*, Pascal André, Jan Novy

Journal Name: Current Neuropharmacology

Volume 17 , Issue 5 , 2019

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Graphical Abstract:


Epilepsy is considered the most frequent severe neurological condition but most patients treated with medication become seizure free. The management of treatment, however, is highly empirical, mainly relying on observation. A closed-loop therapy for epilepsy would be very valuable for more efficient treatment regimens. Here we discuss monitoring treatment (therapeutic drug monitoring) and the potential developments in this field, as well as providing a review of potential biomarkers that could be used to monitor the disease activity. Finally, we consider the pharmacogenetic input in epilepsy treatment.

Keywords: Biomarkers in epilepsy, therapeutic drug monitoring, pharmacogenetics, cytokines, genetic factors, refractory epilepsy, hormones.

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Article Details

Year: 2019
Published on: 04 April, 2019
Page: [447 - 458]
Pages: 12
DOI: 10.2174/1570159X16666180308154646
Price: $65

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