Title:Graphene Oxide as Scaffolds for Stem Cells: An Overview
VOLUME: 17 ISSUE: 9
Author(s):M. Duran, A.C.M. Luzo, J.G. de Souza, W.J. Favaro*, P. Garcia and N. Duran*
Affiliation:Institute of Biology, Urogenital, Carcinogenesis and Immunotherapy Laboratory, Department Genetics, Evolution and Bioagents, University of Campinas, Campinas, SP, Molecular Biology Laboratory, Hematology Hemotherapy Centre, Faculty of Medical Science, University of Campinas, Campinas, SP, Institute of Biology, Urogenital, Carcinogenesis and Immunotherapy Laboratory, Department Genetics, Evolution and Bioagents, University of Campinas, Campinas, SP, Institute of Biology, Urogenital, Carcinogenesis and Immunotherapy Laboratory, Department Genetics, Evolution and Bioagents, University of Campinas, Campinas, SP, Institute of Biology, Urogenital, Carcinogenesis and Immunotherapy Laboratory, Department Genetics, Evolution and Bioagents, University of Campinas, Campinas, SP, NanoBioss-Institute of Chemistry, University of Campinas, Campinas, SP
Keywords:Stem cells, graphene oxide, adipose tissue derived mesenchymal stromal/stem cells, topography,
differentiation, tissue engineering.
Abstract:Graphene and graphene oxide topography have an effect on the fate of stem
cells such as adhesion, differentiation, and proliferation. This overview clearly shows
that a new design and manipulation of associated graphene oxide stem cell culture
platforms are of paramount importance as a focus in stem cell to tissue engineering
applications. This overview also proposes that a film of graphene oxide is an efficient
platform to modulate structure and function of multipotent mesenchymal stem/stromal
cells (MSCs) and in special human adipose tissue derived mesenchymal stromal/stem
cells (AT-MSCs). The implication of graphene oxide on osteogenesis, neurogenesis,
oligodendrogenesis, adipogenic and epithelial differentiation is also discussed.
Graphene oxide toxicity on stem cells and the importance of GO application on ATMSCs
differentiation and proliferation are final topics that are being discussed.
