Title:Role of miR-193a in Cancer: Complexity and Factors Control the Pattern of its Expression
VOLUME: 18 ISSUE: 7
Author(s):Afraa Mamoori, Vinod Gopalan and Alfred K-Y Lam*
Affiliation:Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Cancer Molecular Pathology, School of Medicine, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland
Keywords:miR-193a, cancer, chemotherapy, prognosis, mechanism, methylation.
Abstract:Background: There is emerging data suggesting that the non-coding RNA (microRNA
193a or miR-193a) plays key roles in different types of cancers.
Objective: This review aims to investigate the functional significance of miR-193a in different cancers
according to the information of literature.
Method: All the literature concerning miR-193a in cancer in PubMed are analysed.
Results: Several studies proved the association of miR-193a expression patterns with cancer’s
stages, grades, response to the chemotherapy and even patient survival. Also, miR-193a can be used
to differentiate some types of cancer. In cancer, miR-193a can act as a tumour suppressor gene or as
an oncogene. Till now, several genetic factors (MAX, RXR α, XB130, P63, P73, AEG-1, HIFs,
EGFR, Drosha, DGCR8, Dicer) and epigenetic factors (DNA methylation and long non-coding
RNAs) were predicted to control miR-193a expression. They have fundamental effects on its biological
behaviour in different types of cancers.
Conclusion: miR-193a has significant roles in cancer and can be targeted in the future for cancer
therapy by better understanding of the factors that control its biological behaviour.
