Introduction: A series of seventeen 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea derivatives
(5a-8d) were synthesized and characterized by physical and spectral data (IR, 1H NMR, and mass
spectroscopy) and evaluated for their antibacterial and antifungal activities against various pathogenic
and non-pathogenic microorganisms. Some of the synthesized compounds showed promising antibacterial
and antifungal activities.
Results and Discussions: Many of the tested compounds were found to be significantly active against
gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacterial strains
(Escherichia coli, Salmonella typhi, Klebsiella pneumoniae and Pseudomonas aeruginosa), among
which compounds 5a, 5b, 6a, 6b, 7a, 7b, 8a and 8b showed the maximum anti-bacterial activity but less
effective than the standard ciprofloxacin. Almost all compounds from 5a-8d showed moderate activity
against fungal strains like Candida albicans and Aspergillus niger.