Synthesis, Anti-Microbial Evaluation and Structure Activity Relationship (SAR) Studies of Some 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea Derivatives

Author(s): Rohit Singh*, Swastika Ganguly.

Journal Name: Anti-Infective Agents
Anti-Infective Agents in Medicinal Chemistry

Volume 16 , Issue 1 , 2018

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Graphical Abstract:


Introduction: A series of seventeen 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea derivatives (5a-8d) were synthesized and characterized by physical and spectral data (IR, 1H NMR, and mass spectroscopy) and evaluated for their antibacterial and antifungal activities against various pathogenic and non-pathogenic microorganisms. Some of the synthesized compounds showed promising antibacterial and antifungal activities.

Results and Discussions: Many of the tested compounds were found to be significantly active against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacterial strains (Escherichia coli, Salmonella typhi, Klebsiella pneumoniae and Pseudomonas aeruginosa), among which compounds 5a, 5b, 6a, 6b, 7a, 7b, 8a and 8b showed the maximum anti-bacterial activity but less effective than the standard ciprofloxacin. Almost all compounds from 5a-8d showed moderate activity against fungal strains like Candida albicans and Aspergillus niger.

Keywords: Imidazole derivatives, synthesis, antibacterial, antifungal activities, Anti-Microbial, Staphylococcus aureus.

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Article Details

Year: 2018
Page: [64 - 70]
Pages: 7
DOI: 10.2174/2211352516666180307155830
Price: $25

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